Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP5133 |
Identifying and Prioritizing Chemicals with Uncertain Burden of Exposure: Opportunities for Biomonitoring and Health-Related Research | |
Pellizzari, Edo D.1; Woodruff, Tracey J.2; Boyles, Rebecca R.3; Kannan, Kurunthachalam4; Beamer, Paloma I.5; Buckley, Jessie P.6; Wang, Aolin2; Zhu, Yeyi7,8; Bennett, Deborah H.9 | |
2019-12-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:12 |
文章类型 | Review |
语种 | 英语 |
国家 | USA |
英文摘要 | BACKGROUND: The National Institutes of Health's Environmental influences on Child Health Outcomes (ECHO) initiative aims to understand the impact of environmental factors on childhood disease. Over 40,000 chemicals are approved for commercial use. The challenge is to prioritize chemicals for biomonitoring that may present health risk concerns. OBJECTIVES: Our aim was to prioritize chemicals that may elicit child health effects of interest to ECHO but that have not been biomonitored nationwide and to identify gaps needing additional research. METHODS: We searched databases and the literature for chemicals in environmental media and in consumer products that were potentially toxic. We selected chemicals that were not measured in the National Health and Nutrition Examination Survey. From over 700 chemicals, we chose 155 chemicals and created eight chemical panels. For each chemical, we compiled biomonitoring and toxicity data, U.S. Environmental Protection Agency exposure predictions, and annual production usage. We also applied predictive modeling to estimate toxicity. Using these data, we recommended chemicals either for biomonitoring, to be deferred pending additional data, or as low priority for biomonitoring. RESULTS: For the 155 chemicals, 97 were measured in food or water, 67 in air or house dust, and 52 in biospecimens. We found in vivo endocrine, developmental, reproductive, and neurotoxic effects for 61, 74, 47, and 32 chemicals, respectively. Eighty-six had data from high-throughput in vitro assays. Positive results for endocrine, developmental, neurotoxicity, and obesity were observed for 32, 11, 35, and 60 chemicals, respectively. Predictive modeling results suggested 90% are toxicants. Biomarkers were reported for 76 chemicals. Thirty-six were recommended for biomonitoring. 108 deferred pending additional research, and 11 as low priority for biomonitoring. DISCUSSION: The 108 deferred chemicals included those lacking biomonitoring methods or toxicity data, representing an opportunity for future research. Our evaluation was, in general, limited by the large number of unmeasured or untested chemicals. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000505244800006 |
WOS关键词 | THROUGHPUT SCREENING ASSAYS ; PRIMARY AROMATIC-AMINES ; ENVIRONMENTAL CHEMICALS ; FLAME RETARDANTS ; TRIS(1,3-DICHLORO-2-PROPYL) PHOSPHATE ; ENDOCRINE DISRUPTION ; MASS-SPECTROMETRY ; TOXICITY ; DISPOSITION ; CHILDREN |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/224628 |
专题 | 环境与发展全球科技态势 |
作者单位 | 1.RTI Int, Fellow Program, Res Triangle Pk, NC USA; 2.Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, Program Reprod Hlth & Environm, San Francisco, CA 94143 USA; 3.RTI Int, Bioinformat & Data Sci, Res Triangle Pk, NC USA; 4.New York State Dept Hlth, Wadsworth Ctr, Albany, NY USA; 5.Univ Arizona, Zuckerman Coll Publ Hlth, Dept Commun Environm & Policy, Tucson, AZ USA; 6.Johns Hopkins Univ, Johns Hopkins Bloomberg Sch Publ Heath, Dept Environm Hlth & Engn, Baltimore, MD USA; 7.Kaiser Permanente, Northern Calif Div Res, Oakland, CA USA; 8.Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA; 9.Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA |
推荐引用方式 GB/T 7714 | Pellizzari, Edo D.,Woodruff, Tracey J.,Boyles, Rebecca R.,et al. Identifying and Prioritizing Chemicals with Uncertain Burden of Exposure: Opportunities for Biomonitoring and Health-Related Research[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(12). |
APA | Pellizzari, Edo D..,Woodruff, Tracey J..,Boyles, Rebecca R..,Kannan, Kurunthachalam.,Beamer, Paloma I..,...&Bennett, Deborah H..(2019).Identifying and Prioritizing Chemicals with Uncertain Burden of Exposure: Opportunities for Biomonitoring and Health-Related Research.ENVIRONMENTAL HEALTH PERSPECTIVES,127(12). |
MLA | Pellizzari, Edo D.,et al."Identifying and Prioritizing Chemicals with Uncertain Burden of Exposure: Opportunities for Biomonitoring and Health-Related Research".ENVIRONMENTAL HEALTH PERSPECTIVES 127.12(2019). |
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