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DOI | 10.1289/EHP5057 |
Blood Lead Levels and Risk of Atherosclerosis in the Carotid Artery: Results from a Swedish Cohort | |
Harari, Florencia1,2; Barregard, Lars1,2; Ostling, Gerd3,4; Sallsten, Gerd1,2; Hedblad, Bo3,4; Forsgard, Niklas5; Borne, Yan3,4; Fagerberg, Bjorn6,7; Engstrom, Gunnar3,4 | |
2019-12-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:12 |
文章类型 | Article |
语种 | 英语 |
国家 | Sweden |
英文摘要 | BACKGROUND: Lead exposure has been associated with increased incidence of adverse clinical cardiovascular outcomes. Atherosclerosis has been suggested as one of the underlying mechanisms, and findings from experimental studies support this, but human data are scarce. OBJECTIVES: Our objective was to determine the association between environmental lead exposure based on blood lead (B-Pb) concentrations and the prevalence of atherosclerotic plaque in the carotid artery. METHODS: We used cross-sectional data from the Malmo Diet and Cancer Study cardiovascular cohort (MDCS-CC; recruitment in 1991-1994) covering 4,172 middle-aged men and women. B-Pb at baseline, measured by inductively coupled plasma mass spectrometry, was used as the exposure biomarker. The presence of atherosclerotic plaque in the carotid artery was determined by B-mode ultrasonography. We used logistic regression to estimate odds ratios (ORs) for prevalence of plaque in the carotid artery according to B-Pb quartiles. RESULTS: The median B-Pb was 25 mu g/L (range: 1.5-258), and 36% of the cohort had any atherosclerotic plaque. After controlling for confounders and known cardiovascular risk factors, the OR for prevalence of plaque in the highest quartile (Q4) of B-Pb compared with the lowest quartile (Q1) was 1.35 (95% CI: 1.09, 1.66) in the total group, 1.58 (95% CI: 1.20, 2.08) among women, and 1.18 (95% CI: 0.83, 1.69) among men. Among women, associations were limited to those who were postmenopausal [OR for Q4 vs. Q1 = 1.72 (95% CI: 1.26, 2.34) vs. OR =0.96 (95% CI: 0.49, 1.89 in premenopausal women)]. Associations were weak and nonsignificant in never-smokers [OR for Q4 vs. Q1 = 1.14 (95% CI: 0.81, 1.61)]. DISCUSSION: Our study shows an association between B-Pb concentrations and occurrence of atherosclerotic plaque in the carotid artery, adding evidence for an underlying pro-atherogenic role of lead in cardiovascular disease. Associations appeared to be limited to postmenopausal (vs. premeno-pausal) women. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000505244800005 |
WOS关键词 | INTIMA-MEDIA THICKNESS ; MALMO DIET ; CARDIOVASCULAR-DISEASE ; ENVIRONMENTAL EXPOSURE ; CADMIUM ; PRESSURE ; HYPERTENSION ; POPULATION ; MORTALITY ; PERIOD |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/224627 |
专题 | 环境与发展全球科技态势 |
作者单位 | 1.Sahlgrens Univ Hosp, Occupat & Environm Med, Gothenburg, Sweden; 2.Univ Gothenburg, PB 414, SE-40530 Gothenburg, Sweden; 3.Lund Univ, CRC, Dept Clin Sci Malmo, Malmo, Sweden; 4.Skane Univ Hosp, Malmo, Sweden; 5.Sahlgrens Univ Hosp, Dept Clin Chem, Gothenburg, Sweden; 6.Univ Gothenburg, Wallenberg Lab Cardiovasc & Metab Res, Dept Mol & Clin Med, Gothenburg, Sweden; 7.Sahlgrens Univ Hosp, Gothenburg, Sweden |
推荐引用方式 GB/T 7714 | Harari, Florencia,Barregard, Lars,Ostling, Gerd,et al. Blood Lead Levels and Risk of Atherosclerosis in the Carotid Artery: Results from a Swedish Cohort[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(12). |
APA | Harari, Florencia.,Barregard, Lars.,Ostling, Gerd.,Sallsten, Gerd.,Hedblad, Bo.,...&Engstrom, Gunnar.(2019).Blood Lead Levels and Risk of Atherosclerosis in the Carotid Artery: Results from a Swedish Cohort.ENVIRONMENTAL HEALTH PERSPECTIVES,127(12). |
MLA | Harari, Florencia,et al."Blood Lead Levels and Risk of Atherosclerosis in the Carotid Artery: Results from a Swedish Cohort".ENVIRONMENTAL HEALTH PERSPECTIVES 127.12(2019). |
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