Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHIP5153 |
Early Biological Aging and Fetal Exposure to High and Low Ambient Temperature: A Birth Cohort Study | |
Martens, Dries S.1; Plusquin, Michelle1; Cox, Bianca1; Nawrot, Tim S.1,2 | |
2019-11-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:11 |
文章类型 | Article |
语种 | 英语 |
国家 | Belgium |
英文摘要 | BACKGROUND: Although studies have provided estimates of premature mortality to either heat or cold in adult populations, and fetal exposure to ambient temperature may be associated with life expectancy, the effects of temperature on aging in early life have not yet been studied. Telomere length (TL) is a marker of biological aging, and a short TL at birth may predict lifespan and disease susceptibility later in life. OBJECTIVES: We studied to what extent prenatal ambient temperature exposure is associated with newborn IL. METHODS: In the ENVIRONAGE (ENVIRonmental influence ON early AGEing) birth cohort in Flanders, Belgium, we measured cord blood and placental It in 1,103 mother newborn pairs (singletons with >36 wk of gestation) using a quantitative real-time polymerase chain reaction (qPCR) method. We associated newborn TL with average weekly exposure to ambient temperature using distributed lag nonlinear models (DLNMs) while controlling for potential confounders. Double-threshold DLNMs were used to estimate cold and heat thresholds and the linear associations between temperature and TL below the cold threshold and above the heat threshold. RESULTS: Prenatal temperature exposure above the heat threshold (19.5 degrees C) was associated with shorter cord blood TL. The association with a 1 C increase in temperature was strongest at week 36 of gestation and resulted in a 3.29% [95% confidence interval (CI): 4.67, 1.88] shorter cord blood TL. Consistently, prenatal temperature exposure below the cold threshold (5.0 degrees C) was associated with longer cord blood TL. The association with a 1 C decrease in temperature was strongest at week 10 of gestation with 0.72% (95% CI: 0.46, 0.97) longer cord blood TL. DISCUSSION: Our study supports potential effects of prenatal temperature exposure on longevity and disease susceptibility later in life. Future climate scenarios might jeopardize the potential molecular longevity of future generations from birth onward. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000500762600002 |
WOS关键词 | TELOMERE LENGTH ; BODY-TEMPERATURE ; DISTRIBUTED LAG ; AIR-POLLUTION ; CALORIC RESTRICTION ; HEAT-STRESS ; MODEL CHAIN ; LONGEVITY ; AGE ; PREGNANCY |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/224621 |
专题 | 环境与发展全球科技态势 |
作者单位 | 1.Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium; 2.Leuven Univ, Dept Publ Hlth & Primary Care, Leuven, Belgium |
推荐引用方式 GB/T 7714 | Martens, Dries S.,Plusquin, Michelle,Cox, Bianca,et al. Early Biological Aging and Fetal Exposure to High and Low Ambient Temperature: A Birth Cohort Study[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(11). |
APA | Martens, Dries S.,Plusquin, Michelle,Cox, Bianca,&Nawrot, Tim S..(2019).Early Biological Aging and Fetal Exposure to High and Low Ambient Temperature: A Birth Cohort Study.ENVIRONMENTAL HEALTH PERSPECTIVES,127(11). |
MLA | Martens, Dries S.,et al."Early Biological Aging and Fetal Exposure to High and Low Ambient Temperature: A Birth Cohort Study".ENVIRONMENTAL HEALTH PERSPECTIVES 127.11(2019). |
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