GSTDTAP  > 资源环境科学
DOI10.1289/EHP2619
Plasma Concentrations of Perfluoroalkyl Substances and Risk of Type 2 Diabetes: A Prospective Investigation among US Women
Sun, Qi1,2,3; Zong, Geng1; Valvi, Damaskini4; Nielsen, Flemming5; Coull, Brent4,6; Grandjean, Philippe4,5
2018-03-01
发表期刊ENVIRONMENTAL HEALTH PERSPECTIVES
ISSN0091-6765
EISSN1552-9924
出版年2018
卷号126期号:3
文章类型Article
语种英语
国家USA; Denmark
英文摘要

BACKGROUND: Emerging evidence suggests that perfluoroalkyl substances (PFASs) are endocrine disruptors and may contribute to the etiology of type 2 diabetes (T2D), but this hypothesis needs to be clarified in prospective human studies.


OBJECTIVES: Our objective was to examine the associations between PFAS exposures and subsequent incidence of T2D in the Nurses' Health Study II (NHSII). In addition, we aimed to evaluate potential demographic and lifestyle determinants of plasma PFAS concentrations.


METHODS: A prospective nested case control study of T2D was conducted among participants who were free of diabetes, cardiovascular disease, and cancer in 1995-2000 [(mean +/- SD): 45.3 +/- 4.4 y) of age]. We identified and ascertained 793 incident T2D cases through 2011 (mean +/- SD) years of follow-up: 6.7 +/- 3.7 y). Each case was individually matched to a control (on age, month and fasting status at sample collection, and menopausal status and hormone replacement therapy). Plasma concentrations of five major PFASs, including perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexancsulfonate, perfluorononanoic acid, and perfluorodecanoic acid were measured. Odds ratios (ORs) of T2D by PFAS tertiles were estimated by conditional logistic regression.


RESULTS: Shorter breastfeeding duration and higher intake of certain foods, such as seafood and popcorn, were significantly associated with higher plasma concentrations of PFASs among controls. After multivariate adjustment for T2D risk factors, including body mass index, family history, physical activity, and other covariates, higher plasma concentrations of PFOS and PFOA were associated with an elevated risk of T2D. Comparing extreme tertiles of PFOS or PFOA, ORs were 1.62 (95% Cl: 1.09, 2.41; p(trend) =0.02) and 1.54 (95% CI: 1.04, 2.28; p(trend)=0.03), respectively. Other PFASs were not clearly associated with T2D risk.


CONCLUSIONS: Background exposures to PFASs in the late 1990s were associated with higher T2D risk during the following ears in a prospective case control study of women from the NHSII. These findings support a potential diabetogenic effect of PFAS exposures.


领域资源环境
收录类别SCI-E
WOS记录号WOS:000428419000007
WOS关键词PERSISTENT ORGANIC POLLUTANTS ; PERFLUOROOCTANOIC ACID EXPOSURE ; ACTIVATED-RECEPTOR-ALPHA ; NUCLEAR FACTOR 4-ALPHA ; PERFLUORINATED COMPOUNDS ; GLUCOSE-HOMEOSTASIS ; PPAR-GAMMA ; ENDOCRINE DISRUPTORS ; POSTMENOPAUSAL WOMEN ; SERUM CONCENTRATIONS
WOS类目Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
WOS研究方向Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/22460
专题资源环境科学
作者单位1.Harvard TH Chan Sch Publ Hlth, Dept Nutr, 665 Huntington Ave, Boston, MA 02115 USA;
2.Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;
3.Harvard Med Sch, Boston, MA USA;
4.Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA;
5.Univ Southern Denmark, Inst Publ Hlth, Odense, Denmark;
6.Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA
推荐引用方式
GB/T 7714
Sun, Qi,Zong, Geng,Valvi, Damaskini,et al. Plasma Concentrations of Perfluoroalkyl Substances and Risk of Type 2 Diabetes: A Prospective Investigation among US Women[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2018,126(3).
APA Sun, Qi,Zong, Geng,Valvi, Damaskini,Nielsen, Flemming,Coull, Brent,&Grandjean, Philippe.(2018).Plasma Concentrations of Perfluoroalkyl Substances and Risk of Type 2 Diabetes: A Prospective Investigation among US Women.ENVIRONMENTAL HEALTH PERSPECTIVES,126(3).
MLA Sun, Qi,et al."Plasma Concentrations of Perfluoroalkyl Substances and Risk of Type 2 Diabetes: A Prospective Investigation among US Women".ENVIRONMENTAL HEALTH PERSPECTIVES 126.3(2018).
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