Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP2619 |
Plasma Concentrations of Perfluoroalkyl Substances and Risk of Type 2 Diabetes: A Prospective Investigation among US Women | |
Sun, Qi1,2,3; Zong, Geng1; Valvi, Damaskini4; Nielsen, Flemming5; Coull, Brent4,6; Grandjean, Philippe4,5 | |
2018-03-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2018 |
卷号 | 126期号:3 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Denmark |
英文摘要 | BACKGROUND: Emerging evidence suggests that perfluoroalkyl substances (PFASs) are endocrine disruptors and may contribute to the etiology of type 2 diabetes (T2D), but this hypothesis needs to be clarified in prospective human studies. OBJECTIVES: Our objective was to examine the associations between PFAS exposures and subsequent incidence of T2D in the Nurses' Health Study II (NHSII). In addition, we aimed to evaluate potential demographic and lifestyle determinants of plasma PFAS concentrations. METHODS: A prospective nested case control study of T2D was conducted among participants who were free of diabetes, cardiovascular disease, and cancer in 1995-2000 [(mean +/- SD): 45.3 +/- 4.4 y) of age]. We identified and ascertained 793 incident T2D cases through 2011 (mean +/- SD) years of follow-up: 6.7 +/- 3.7 y). Each case was individually matched to a control (on age, month and fasting status at sample collection, and menopausal status and hormone replacement therapy). Plasma concentrations of five major PFASs, including perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexancsulfonate, perfluorononanoic acid, and perfluorodecanoic acid were measured. Odds ratios (ORs) of T2D by PFAS tertiles were estimated by conditional logistic regression. RESULTS: Shorter breastfeeding duration and higher intake of certain foods, such as seafood and popcorn, were significantly associated with higher plasma concentrations of PFASs among controls. After multivariate adjustment for T2D risk factors, including body mass index, family history, physical activity, and other covariates, higher plasma concentrations of PFOS and PFOA were associated with an elevated risk of T2D. Comparing extreme tertiles of PFOS or PFOA, ORs were 1.62 (95% Cl: 1.09, 2.41; p(trend) =0.02) and 1.54 (95% CI: 1.04, 2.28; p(trend)=0.03), respectively. Other PFASs were not clearly associated with T2D risk. CONCLUSIONS: Background exposures to PFASs in the late 1990s were associated with higher T2D risk during the following ears in a prospective case control study of women from the NHSII. These findings support a potential diabetogenic effect of PFAS exposures. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000428419000007 |
WOS关键词 | PERSISTENT ORGANIC POLLUTANTS ; PERFLUOROOCTANOIC ACID EXPOSURE ; ACTIVATED-RECEPTOR-ALPHA ; NUCLEAR FACTOR 4-ALPHA ; PERFLUORINATED COMPOUNDS ; GLUCOSE-HOMEOSTASIS ; PPAR-GAMMA ; ENDOCRINE DISRUPTORS ; POSTMENOPAUSAL WOMEN ; SERUM CONCENTRATIONS |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22460 |
专题 | 资源环境科学 |
作者单位 | 1.Harvard TH Chan Sch Publ Hlth, Dept Nutr, 665 Huntington Ave, Boston, MA 02115 USA; 2.Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA; 3.Harvard Med Sch, Boston, MA USA; 4.Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA; 5.Univ Southern Denmark, Inst Publ Hlth, Odense, Denmark; 6.Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA |
推荐引用方式 GB/T 7714 | Sun, Qi,Zong, Geng,Valvi, Damaskini,et al. Plasma Concentrations of Perfluoroalkyl Substances and Risk of Type 2 Diabetes: A Prospective Investigation among US Women[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2018,126(3). |
APA | Sun, Qi,Zong, Geng,Valvi, Damaskini,Nielsen, Flemming,Coull, Brent,&Grandjean, Philippe.(2018).Plasma Concentrations of Perfluoroalkyl Substances and Risk of Type 2 Diabetes: A Prospective Investigation among US Women.ENVIRONMENTAL HEALTH PERSPECTIVES,126(3). |
MLA | Sun, Qi,et al."Plasma Concentrations of Perfluoroalkyl Substances and Risk of Type 2 Diabetes: A Prospective Investigation among US Women".ENVIRONMENTAL HEALTH PERSPECTIVES 126.3(2018). |
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