Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP2246 |
Traffic-Related Air Pollution, APOE epsilon 4 Status, and Neurodevelopmental Outcomes among School Children Enrolled in the BREATHE Project (Catalonia, Spain) | |
Alemany, Silvia1,2,3; Vilor-Tejedor, Natalia1,2,3,4; Garcia-Esteban, Raquel1,2,3; Bustamante, Mariona1,2,3,4; Dadvand, Payam1,2,3; Esnaola, Mikel1,2,3; Mortamais, Marion1,2,3; Forns, Joan1,2,3; van Drooge, Barend L.5; Alvarez-Pedrerol, Mar1,2,3; Grimalt, Joan O.5; Rivas, Ioar1,2,3,5; Querol, Xavier5; Pujol, Jesus6,7; Sunyer, Jordi1,2,3,8 | |
2018-08-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2018 |
卷号 | 126期号:8 |
文章类型 | Article |
语种 | 英语 |
国家 | Spain |
英文摘要 | BACKGROUND: Traffic-related air pollution is emerging as a risk factor for Alzheimer's disease (AD) and impaired brain development. Individual differences in vulnerability to air pollution may involve the epsilon 4 allele of Apolipoprotein E (APOE) gene, the primary genetic risk factor for AD. OBJECTIVE: We analyzed whether the association between traffic air pollution and neurodevelopmental outcomes is modified by A POE epsilon 4 status in children. METHODS: Data on parent-reported behavior problems (total difficulties scores, Strengths and Difficulties Questionnaire), eacher-reported attention deficit hyperactivity disorder (ADHD) symptom scores, cognitive performance trajectories (computerized tests of inattentiveness and working memory repeated 2-4 times during January 2012-March 2013), and APOE genotypes were obtained for 1,667 children age 7-11 y attending 39 schools in or near Barcelona. Basal ganglia volume (putamen, caudate, and globus pallidum) was measured in 163 of the children by MRI (October 2012-April 2014.) Average annual outdoor polycyclic aromatic hydrocarbons (PAHs), elemental carbon (EC), and nitrogen dioxide (NO2) concentrations were estimated based on measurements at each school (two 1-wk campaigns conducted 6 months apart in 2012). RESULTS: APOE epsilon 4 allele carriers had significantly higher behavior problem scores than noncarriers, and adverse associations with PAHs and NO2 were stronger or limited to epsilon 4 carriers for behavior problem scores (P-interaction 0.03 and 0.04), caudate volume (P-interaction 0.04 and 0.03), and inattentiveness trajectories (P-interaction 0.15 and 0.08, respectively). Patterns of associations with the same outcomes were similar for EC. CONCLUSION: PAHs, EC, and NO2 were associated with higher behavior problem scores, smaller reductions in inattentiveness over time, and smaller caudate volume in APOE epsilon 4 allele carriers in our study population, and corresponding associations were weak or absent among epsilon 4 noncaniers. These findings support a potential role of APOE in biological mechanisms that may contribute to associations between air pollution and neurobehavioral outcomes in children. |
领域 | 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000444417500001 |
WOS关键词 | POLYCYCLIC AROMATIC-HYDROCARBONS ; WORKING-MEMORY ; NEUROPSYCHOLOGICAL DEVELOPMENT ; COGNITIVE FUNCTION ; PRENATAL EXPOSURE ; OXIDATIVE STRESS ; BRAIN STRUCTURE ; DISEASE ; ASSOCIATION ; BARCELONA |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22452 |
专题 | 资源环境科学 |
作者单位 | 1.ISGlobal, Barcelona Inst Global Hlth, C Doctor Aiguader 88, Barcelona 08003, Spain; 2.UPF, Barcelona, Spain; 3.CIBERESP, Barcelona, Spain; 4.Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, Barcelona, Spain; 5.Inst Environm Assessment & Water Res IDAEA CSIC, Barcelona, Spain; 6.Hosp Mar, Dept Radiol, MRI Res Unit, Barcelona, Spain; 7.Ctr Invest Biomed Red Salud Mental CIBERSAM G21, Barcelona, Spain; 8.IMIM Hosp Mar Med Res Inst, Barcelona, Spain |
推荐引用方式 GB/T 7714 | Alemany, Silvia,Vilor-Tejedor, Natalia,Garcia-Esteban, Raquel,et al. Traffic-Related Air Pollution, APOE epsilon 4 Status, and Neurodevelopmental Outcomes among School Children Enrolled in the BREATHE Project (Catalonia, Spain)[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2018,126(8). |
APA | Alemany, Silvia.,Vilor-Tejedor, Natalia.,Garcia-Esteban, Raquel.,Bustamante, Mariona.,Dadvand, Payam.,...&Sunyer, Jordi.(2018).Traffic-Related Air Pollution, APOE epsilon 4 Status, and Neurodevelopmental Outcomes among School Children Enrolled in the BREATHE Project (Catalonia, Spain).ENVIRONMENTAL HEALTH PERSPECTIVES,126(8). |
MLA | Alemany, Silvia,et al."Traffic-Related Air Pollution, APOE epsilon 4 Status, and Neurodevelopmental Outcomes among School Children Enrolled in the BREATHE Project (Catalonia, Spain)".ENVIRONMENTAL HEALTH PERSPECTIVES 126.8(2018). |
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