Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP1014 |
Endocrine Disruption in Human Fetal Testis Explants by Individual and Combined Exposures to Selected Pharmaceuticals, Pesticides, and Environmental Pollutants | |
Gaudriault, Pierre1,2; Mazaud-Guittot, Severine1,2; Lavoue, Vincent3; Coiffec, Isabelle1,2; Lesne, Laurianne1,2; Dejucq-Rainsford, Nathalie1,2; Scholze, Martin4; Kortenkamp, Andreas4; Jegou, Bernard1,2,5 | |
2017-08-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:8 |
文章类型 | Article |
语种 | 英语 |
国家 | France; England |
英文摘要 | BACKGROUND: Numerous chemicals are capable of disrupting androgen production, but the possibility that they might act together to produce effects greater than those of the most effective component in the mixture has not been studied directly in human tissues. Suppression of androgen synthesis in fetal life has been associated with testis maldescent, malformations of the genitalia at birth, and poor semen quality later in life. OBJECTIVES: Our aim was to investigate whether chemicals can act together to disrupt androgen production in human fetal testis explants and to evaluate the importance of mixture effects when characterizing the hazard of individual chemicals. METHODS: We used an organotypic culture system of human fetal testes explants called FEtal Gonad Assay (FEGA) with tissue obtained at 10 and 12 gestational wk (GW 10-12), to screen 27 chemicals individually for their possible anti -androgenic effect. Based on the results of the screen, we selected 11 compounds and tested them as mixtures. RESULTS: We evaluated mixtures composed of four and eight antiandrogens that contained the pharmaceuticals ketoconazole and theophylline and several previously untested chemicals, such as the pesticides imazalil and propiconazole. Mixtures of antiandrogens can suppress testosterone synthesis in human fetal testicular explants to an extent greater than that seen with individual chemicals. This revealed itself as a shift towards lower doses in the dose -response curves of individual antiandrogens that became more pronounced as the number of components increased from four to eight. CONCLUSIONS: Our results with the -LEGA provide the foundations of a predictive human mixture risk assessment approach for anti androgenic exposures in fetal life. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413790600014 |
WOS关键词 | IN-VITRO ; ANTI-ANDROGENS ; MIXTURES ; RATS ; SUSCEPTIBILITY ; PREVALENCE ; DISORDERS ; HEALTH ; RISK ; VIVO |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22439 |
专题 | 资源环境科学 |
作者单位 | 1.INSERM, UMR1085, IRSET, Rennes, France; 2.Univ Rennes 1, Rennes, France; 3.CHU Rennes, Serv Gynecol & Obstet, Rennes, France; 4.Brunel Univ London, Inst Environm Hlth & Soc, Uxbridge, Middx, England; 5.EHESP, Sch Publ Hlth, Rennes, France |
推荐引用方式 GB/T 7714 | Gaudriault, Pierre,Mazaud-Guittot, Severine,Lavoue, Vincent,et al. Endocrine Disruption in Human Fetal Testis Explants by Individual and Combined Exposures to Selected Pharmaceuticals, Pesticides, and Environmental Pollutants[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(8). |
APA | Gaudriault, Pierre.,Mazaud-Guittot, Severine.,Lavoue, Vincent.,Coiffec, Isabelle.,Lesne, Laurianne.,...&Jegou, Bernard.(2017).Endocrine Disruption in Human Fetal Testis Explants by Individual and Combined Exposures to Selected Pharmaceuticals, Pesticides, and Environmental Pollutants.ENVIRONMENTAL HEALTH PERSPECTIVES,125(8). |
MLA | Gaudriault, Pierre,et al."Endocrine Disruption in Human Fetal Testis Explants by Individual and Combined Exposures to Selected Pharmaceuticals, Pesticides, and Environmental Pollutants".ENVIRONMENTAL HEALTH PERSPECTIVES 125.8(2017). |
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