GSTDTAP  > 资源环境科学
DOI10.1289/EHP1062
Exposure to Perfluoroalkyl Substances and Metabolic Outcomes in Pregnant Women: Evidence from the Spanish INMA Birth Cohorts
Matilla-Santander, Nuria1,2,3; Valvi, Damaskini1,2,3,4; Lopez-Espinosa, Maria-Jose3,5; Manzano-Salgado, Cyntia B.1,2,3; Ballester, Ferran3,5; Ibarluzea, Jesus3,6,7; Santa-Marina, Loreto3,6,7; Schettgen, Thomas8; Guxens, Monica1,2,3,9; Sunyer, Jordi1,2,3; Vrijheid, Martine1,2,3
2017-11-01
发表期刊ENVIRONMENTAL HEALTH PERSPECTIVES
ISSN0091-6765
EISSN1552-9924
出版年2017
卷号125期号:11
文章类型Article
语种英语
国家Spain; USA; Germany; Netherlands
英文摘要

BACKGROUND: Exposure to perfluoroalkyl substances (PFASs) may increase risk for metabolic diseases; however, epidemiologic evidence is lacking at the present time. Pregnancy is a period of enhanced tissue plasticity for the fetus and the mother and may be a critical window of PFAS exposure susceptibility.


OBJECTIVE: We evaluated the associations between PFAS exposures and metabolic outcomes in pregnant women.


METHODS: We analyzed 1,240 pregnant women from the Spanish INMA [Environment and Childhood Project (INfancia y Medio Ambiente)] birth cohort study (recruitment period: 2003-2008) with measured first pregnancy trimester plasma concentrations of four PFASs (in nanograms/milliliter). We used logistic regression models to estimate associations of PFASs (log(10)-transformed and categorized into quartiles) with impaired glucose tolerance (IGT) and gestational diabetes mellitus (GDM), and we used linear regression models to estimate associations with first-trimester serum levels of triglycerides, total cholesterol, and C-reactive protein (CRP).


RESULTS: Perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonate (PFHxS) were positively associated with IGT (137 cases) [OR per log10-unit increase=1.99 (95% CI: 1.06, 3.78) and OR=1.65 ( 95% CI: 0.99, 2.76), respectively]. PFOS and PFHxS associations with GDM (53 cases) were in a similar direction, but less precise. PFOS and perfluorononanoate (PFNA) were negatively associated with triglyceride levels [percent median change per log10-unit increase=-5.86% (95% CI: -9.91%, -1.63%) and percent median change per log10-unit increase=-4.75% (95% CI: -8.16%, -0.61%, respectively], whereas perfluorooctanoate (PFOA) was positively associated with total cholesterol [percent median change per log10-unit increase=1.26% (95% CI: 0.01%, 2.54%)]. PFASs were not associated with CRP in the subset of the population with available data (n=640).


CONCLUSIONS: Although further confirmation is required, the findings from this study suggest that PFAS exposures during pregnancy may influence lipid metabolism and glucose tolerance and thus may impact the health of the mother and her child.


领域资源环境
收录类别SCI-E
WOS记录号WOS:000416837300001
WOS关键词ENDOCRINE DISRUPTORS ; SERUM CONCENTRATIONS ; POLYFLUOROALKYL SUBSTANCES ; GLUCOSE-HOMEOSTASIS ; PPAR-ALPHA ; ACIDS ; RISK ; ASSOCIATION ; PREDICTORS ; PERFLUOROOCTANOATE
WOS类目Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
WOS研究方向Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/22386
专题资源环境科学
作者单位1.Ctr Res Environm Epidemiol CREAL, ISGlobal, 88 Doctor Aiguader, Barcelona 08003, Catalonia, Spain;
2.UPF, Barcelona, Spain;
3.Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain;
4.Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA;
5.Univ Valencia, FISABIO, Epidemiol & Environm Hlth Joint Res Unit, Valencia, Spain;
6.Subdirecc Salud Publ & Adicc Gipuzkoa, San Sebastian, Spain;
7.Inst Invest Sanitaria Biodonostia, San Sebastian, Spain;
8.Rhein Westfal TH Aachen, RWTH, Inst Occupat Med, Aachen, Germany;
9.Erasmus Univ, Med Ctr, Sophia Childrens Hosp, Dept Child & Adolescent Psychiat Psychol, Rotterdam, Netherlands
推荐引用方式
GB/T 7714
Matilla-Santander, Nuria,Valvi, Damaskini,Lopez-Espinosa, Maria-Jose,et al. Exposure to Perfluoroalkyl Substances and Metabolic Outcomes in Pregnant Women: Evidence from the Spanish INMA Birth Cohorts[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(11).
APA Matilla-Santander, Nuria.,Valvi, Damaskini.,Lopez-Espinosa, Maria-Jose.,Manzano-Salgado, Cyntia B..,Ballester, Ferran.,...&Vrijheid, Martine.(2017).Exposure to Perfluoroalkyl Substances and Metabolic Outcomes in Pregnant Women: Evidence from the Spanish INMA Birth Cohorts.ENVIRONMENTAL HEALTH PERSPECTIVES,125(11).
MLA Matilla-Santander, Nuria,et al."Exposure to Perfluoroalkyl Substances and Metabolic Outcomes in Pregnant Women: Evidence from the Spanish INMA Birth Cohorts".ENVIRONMENTAL HEALTH PERSPECTIVES 125.11(2017).
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