Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP1062 |
Exposure to Perfluoroalkyl Substances and Metabolic Outcomes in Pregnant Women: Evidence from the Spanish INMA Birth Cohorts | |
Matilla-Santander, Nuria1,2,3; Valvi, Damaskini1,2,3,4; Lopez-Espinosa, Maria-Jose3,5; Manzano-Salgado, Cyntia B.1,2,3; Ballester, Ferran3,5; Ibarluzea, Jesus3,6,7; Santa-Marina, Loreto3,6,7; Schettgen, Thomas8; Guxens, Monica1,2,3,9; Sunyer, Jordi1,2,3; Vrijheid, Martine1,2,3 | |
2017-11-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:11 |
文章类型 | Article |
语种 | 英语 |
国家 | Spain; USA; Germany; Netherlands |
英文摘要 | BACKGROUND: Exposure to perfluoroalkyl substances (PFASs) may increase risk for metabolic diseases; however, epidemiologic evidence is lacking at the present time. Pregnancy is a period of enhanced tissue plasticity for the fetus and the mother and may be a critical window of PFAS exposure susceptibility. OBJECTIVE: We evaluated the associations between PFAS exposures and metabolic outcomes in pregnant women. METHODS: We analyzed 1,240 pregnant women from the Spanish INMA [Environment and Childhood Project (INfancia y Medio Ambiente)] birth cohort study (recruitment period: 2003-2008) with measured first pregnancy trimester plasma concentrations of four PFASs (in nanograms/milliliter). We used logistic regression models to estimate associations of PFASs (log(10)-transformed and categorized into quartiles) with impaired glucose tolerance (IGT) and gestational diabetes mellitus (GDM), and we used linear regression models to estimate associations with first-trimester serum levels of triglycerides, total cholesterol, and C-reactive protein (CRP). RESULTS: Perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonate (PFHxS) were positively associated with IGT (137 cases) [OR per log10-unit increase=1.99 (95% CI: 1.06, 3.78) and OR=1.65 ( 95% CI: 0.99, 2.76), respectively]. PFOS and PFHxS associations with GDM (53 cases) were in a similar direction, but less precise. PFOS and perfluorononanoate (PFNA) were negatively associated with triglyceride levels [percent median change per log10-unit increase=-5.86% (95% CI: -9.91%, -1.63%) and percent median change per log10-unit increase=-4.75% (95% CI: -8.16%, -0.61%, respectively], whereas perfluorooctanoate (PFOA) was positively associated with total cholesterol [percent median change per log10-unit increase=1.26% (95% CI: 0.01%, 2.54%)]. PFASs were not associated with CRP in the subset of the population with available data (n=640). CONCLUSIONS: Although further confirmation is required, the findings from this study suggest that PFAS exposures during pregnancy may influence lipid metabolism and glucose tolerance and thus may impact the health of the mother and her child. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000416837300001 |
WOS关键词 | ENDOCRINE DISRUPTORS ; SERUM CONCENTRATIONS ; POLYFLUOROALKYL SUBSTANCES ; GLUCOSE-HOMEOSTASIS ; PPAR-ALPHA ; ACIDS ; RISK ; ASSOCIATION ; PREDICTORS ; PERFLUOROOCTANOATE |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22386 |
专题 | 资源环境科学 |
作者单位 | 1.Ctr Res Environm Epidemiol CREAL, ISGlobal, 88 Doctor Aiguader, Barcelona 08003, Catalonia, Spain; 2.UPF, Barcelona, Spain; 3.Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain; 4.Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA; 5.Univ Valencia, FISABIO, Epidemiol & Environm Hlth Joint Res Unit, Valencia, Spain; 6.Subdirecc Salud Publ & Adicc Gipuzkoa, San Sebastian, Spain; 7.Inst Invest Sanitaria Biodonostia, San Sebastian, Spain; 8.Rhein Westfal TH Aachen, RWTH, Inst Occupat Med, Aachen, Germany; 9.Erasmus Univ, Med Ctr, Sophia Childrens Hosp, Dept Child & Adolescent Psychiat Psychol, Rotterdam, Netherlands |
推荐引用方式 GB/T 7714 | Matilla-Santander, Nuria,Valvi, Damaskini,Lopez-Espinosa, Maria-Jose,et al. Exposure to Perfluoroalkyl Substances and Metabolic Outcomes in Pregnant Women: Evidence from the Spanish INMA Birth Cohorts[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(11). |
APA | Matilla-Santander, Nuria.,Valvi, Damaskini.,Lopez-Espinosa, Maria-Jose.,Manzano-Salgado, Cyntia B..,Ballester, Ferran.,...&Vrijheid, Martine.(2017).Exposure to Perfluoroalkyl Substances and Metabolic Outcomes in Pregnant Women: Evidence from the Spanish INMA Birth Cohorts.ENVIRONMENTAL HEALTH PERSPECTIVES,125(11). |
MLA | Matilla-Santander, Nuria,et al."Exposure to Perfluoroalkyl Substances and Metabolic Outcomes in Pregnant Women: Evidence from the Spanish INMA Birth Cohorts".ENVIRONMENTAL HEALTH PERSPECTIVES 125.11(2017). |
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