Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP261 |
Individual and Joint Effects of Early-Life Ambient PM2.5 Exposure and Maternal Prepregnancy Obesity on Childhood Overweight or Obesity | |
Mao, Guangyun1,2,3; Nachman, Rebecca Massa4; Suns, Qi5,6,7; Zhang, Xingyou8; Koehler, Kirsten4; Chen, Zhu3; Hong, Xiumei3; Wang, Guoying3; Caruso, Deanna3; Zong, Geng7; Pearson, Colleen9,10; Ji, Hongkai11; Biswal, Shyam4; Zuckerman, Barry9,10; Wills-Karp, Marsha4; Wang, Xiaobin3 | |
2017-06-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:6 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA |
英文摘要 | BACKGROUND: Although previous studies suggest that exposure to traffic-related pollution during childhood increases the risk of childhood overweight or obesity (COWO), the role of early life exposure to line particulate matter (aerodynamic diameter <2.5 mu m; PM2.5) and its joint effect with the mother's prepregnancy body mass index (MPBMI) on COWO remain unclear. OBJECTIVES: The present study was conducted to examine the individual and joint effects of ambient PM2.5 exposures and MPBMI on the risk of COW. METHODS: We estimated exposures to ambient PM2.5 in utero and during the first 2 y of life (E2YL), using data from the U.S. Environmental Protection Agency's (EPA's) Air Quality System matched to residential address, in 1,446 mother infant pairs who were recruited at birth from 1998 and followed up prospectively through 2012 at the Boston Medical Center in Massachusetts. We quantified the individual and joint effects of PM2.5 exposure with MPBMI on COWO, defined as the child's age- and sex-specific BMI z-score >85th percentile at the last well-child care visit between 2 and 9 y of age. Additivity was assessed by estimating the reduced excess risk due to interaction. RESULTS: Comparing the highest and lowest quartiles of PM2.5, the adjusted relative risks (RRs) [95% confidence intervals (CIs)] of COWO were 1.3 (95% CI: 1.1, 1.5), 1.2 (95% CI: 1.0, 1.4), 1.2 (95% CI: 1.0, 1.4), 1.3 (95% CI: 1.1, 1.6), 1.3 (95% CI: 1.1, 1.5) and 1.3 (1.1, 1.5) during preconception; the first, second, and third trimesters; the entire period of pregnancy; and F2YL, respectively. Spline regression showed a dose response relationship between PM2.5 levels and COWO after a threshold near the median exposure (10.46 mu g/m(3)-10.89 mu g/m(3)). Compared with their counterparts, children of obese mothers exposed to high levels of PM2.5 had the highest risk of COWO [RR >= 2.0, relative excess risk due to interaction (RERI) not significant]. CONCLUSIONS: In the present study, we observed that early life exposure to PM2.5 may play an important role in the early life origins of COWO and may increase the risk of COWO in children of mothers who were overweight or obese before pregnancy beyond the risk that can be attributed to MPBMI alone. Our findings emphasize the clinical and public health policy relevance of early life PM2.5 exposure. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413788400014 |
WOS关键词 | BODY-MASS INDEX ; AIR-POLLUTION ; LONGITUDINAL COHORT ; METABOLIC SYNDROME ; TRAFFIC POLLUTION ; BIRTH-WEIGHT ; RISK-FACTORS ; CHILDREN ; ASSOCIATION ; PARTICLES |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22381 |
专题 | 资源环境科学 |
作者单位 | 1.Wenzhou Med Univ, Sch Environm Sci & Publ Hlth, Dept Prevent Med, Wenzhou, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Ctr Clin & Epidemiol Eye Res, Affiliated Eye Hosp, Wenzhou, Zhejiang, Peoples R China; 3.Johns Hopkins Univ, Dept Populat Family & Reprod Hlth, Ctr Early Life Origins Dis, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA; 4.Johns Hopkins Univ, Dept Environm Hlth Sci, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA; 5.Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA; 6.Harvard Med Sch, Boston, MA USA; 7.Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA; 8.Childrens Mem Res Ctr, Mary Ann & J Milburn Smith Child Hlth Res Program, Chicago, IL USA; 9.Boston Univ, Sch Med, Dept Pediat, Boston, MA 02118 USA; 10.Boston Med Ctr, Boston, MA USA; 11.Johns Hopkins Univ, Dept Biostat, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA |
推荐引用方式 GB/T 7714 | Mao, Guangyun,Nachman, Rebecca Massa,Suns, Qi,et al. Individual and Joint Effects of Early-Life Ambient PM2.5 Exposure and Maternal Prepregnancy Obesity on Childhood Overweight or Obesity[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(6). |
APA | Mao, Guangyun.,Nachman, Rebecca Massa.,Suns, Qi.,Zhang, Xingyou.,Koehler, Kirsten.,...&Wang, Xiaobin.(2017).Individual and Joint Effects of Early-Life Ambient PM2.5 Exposure and Maternal Prepregnancy Obesity on Childhood Overweight or Obesity.ENVIRONMENTAL HEALTH PERSPECTIVES,125(6). |
MLA | Mao, Guangyun,et al."Individual and Joint Effects of Early-Life Ambient PM2.5 Exposure and Maternal Prepregnancy Obesity on Childhood Overweight or Obesity".ENVIRONMENTAL HEALTH PERSPECTIVES 125.6(2017). |
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