Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP1013 |
Pesticide Exposure and Risk of Rheumatoid Arthritis among Licensed Male Pesticide Applicators in the Agricultural Health Study | |
Meyer, Armando1; Sandler, Dale P.2; Freeman, Laura E. Beane3; Hofmann, Jonathan N.3; Parks, Christine G.2 | |
2017-07-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:7 |
文章类型 | Article |
语种 | 英语 |
国家 | Brazil; USA |
英文摘要 | BACKGROUND: The occupation of farming has been associated with rheumatoid arthritis (RA); pesticides may account for this association, but there are few studies. OBJECTIVES: We investigated associations between RA and use of pesticides in the Agricultural Health Study. METHODS: The study sample was drawn from male pesticide applicators enrolled in 1993-1997 who provided questionnaire data at baseline and at least once during follow-up (over a median 18 y; interquartile range 16-19). Incident RA cases (n = 220), confirmed by physicians or by self-reported use of disease-modifying antirheumatic drugs, were compared with noncases (n = 26,134) who did not report RA. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression, adjusting for enrollment age, state, smoking pack-years, and education. We evaluated the association of RA with the use of 46 pesticides and across 4 levels (never use and tertiles) of lifetime days of use for 16 pesticides with OR >= 1.2 for ever use. RESULTS: Incident RA was associated with ever use of fonofos (OR = 1.70; 95% CI: 1.22, 2.37), carharyl (OR = 1.51; 95% CI: 1.03, 2.23), and chlorimuron ethyl (OR = 1.45; 95% CI: 1.01, 2.07) compared with never use. Statistically significant exposure response trends in association with RA were observed for lifetime days of use of atrazine [ORtertile3 = 1.62 (95% CI: 1.09, 2.40); p(trend) = 0.01] and [ORtertile3 = 2.42 (95% CI: 1.03, 5.68); p(trend) = 0.02]. Exposure response was nonlinear for fonofos [ORtertile1 = 2.27 (95% CI: 1.44, 3.57); ORtertile2 = 0.98 (95% CI: 0.54, 1.80); ORtertile3 = 2.10 (95% CI: 1.32, 3.36); p(trend) = 0.005] and suggestive for carbaryl (p(trend) = 0.053). CONCLUSIONS: Our results provide novel evidence of associations between exposure to some pesticides and RA in male farmers. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413791300018 |
WOS关键词 | SYSTEMIC-LUPUS-ERYTHEMATOSUS ; WOMENS HEALTH ; IN-VITRO ; UNITED-STATES ; DISEASE ; EPIDEMIOLOGY ; MORTALITY ; IMMUNOTOXICITY ; REGISTER ; COHORT |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22378 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Fed Rio de Janeiro, Publ Hlth Inst, Occupat & Environm Hlth Branch, Rio De Janeiro, Brazil; 2.NIEHS, Epidemiol Branch, NIH, US Dept HHS, Res Triangle Pk, NC 27599 USA; 3.NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,US Dept HHS, Bethesda, MD 20892 USA |
推荐引用方式 GB/T 7714 | Meyer, Armando,Sandler, Dale P.,Freeman, Laura E. Beane,et al. Pesticide Exposure and Risk of Rheumatoid Arthritis among Licensed Male Pesticide Applicators in the Agricultural Health Study[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(7). |
APA | Meyer, Armando,Sandler, Dale P.,Freeman, Laura E. Beane,Hofmann, Jonathan N.,&Parks, Christine G..(2017).Pesticide Exposure and Risk of Rheumatoid Arthritis among Licensed Male Pesticide Applicators in the Agricultural Health Study.ENVIRONMENTAL HEALTH PERSPECTIVES,125(7). |
MLA | Meyer, Armando,et al."Pesticide Exposure and Risk of Rheumatoid Arthritis among Licensed Male Pesticide Applicators in the Agricultural Health Study".ENVIRONMENTAL HEALTH PERSPECTIVES 125.7(2017). |
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