Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP2358 |
Prenatal Phthalates, Maternal Thyroid Function, and Risk of Attention-Deficit Hyperactivity Disorder in the Norwegian Mother and Child Cohort | |
Engel, Stephanie M.1; Villanger, Gro D.2; Nethery, Rachel C.3; Thomsen, Cathrine4; Sakhi, Amrit K.4; Drover, Samantha S. M.1; Hoppin, Jane A.5; Zeiner, Pal6; Knudsen, Gun Peggy7; Reichborn-Kjennerud, Ted8,9; Herring, Amy H.10,11; Aase, Heidi2 | |
2018-05-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2018 |
卷号 | 126期号:5 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Norway |
英文摘要 | BACKGROUND: There is growing concern that phthalate exposures may have an impact on child neurodevelopment. Prenatal exposure to phthalates has been linked with externalizing behaviors and executive functioning defects suggestive of an attention-deficit hyperactivity disorder (ADHD) phenotype. OBJECTIVES: We undertook an investigation into whether prenatal exposure to phthalates was associated with clinically confirmed ADHD in a population-based nested case control study of the Norwegian Mother and Child Cohort (MoBa) between the years 2003 and 2008. METHODS: Phthalate metabolites were measured in maternal urine collected at midpregnancy. Cases of ADHD (n = 297) were obtained through linkage between MoBa and the Norwegian National Patient Registry. A random sample of controls (n = 553) from the MoBa population was obtained. RESULTS: In multivariable adjusted coexposure models, the sum of di-2-ethylhexyl phthalate metabolites (Sigma DEBP) was associated with a monotonically increasing risk of ADHD. Children of mothers in the highest quintile of Sigma DEHP had almost three times the odds of an ADHD diagnosis as those in the lowest [OR = 2.99 (95% CI: 1.47, 5.49)]. When Sigma DEHP was modeled as a log-linear (natural log) term, for each log-unit increase in exposure, the odds of ADHD increased by 47% [OR = 1.47 (95% CI: 1.09, 1..94)]. We detected no significant modification by sex or mediation by prenatal maternal thyroid function or by preterm delivery. CONCLUSIONS: In this population-based case control study of clinical ADHD, maternal urinary concentrations of DEHP were monotonically associated with increased risk of ADHD. Additional research is needed to evaluate potential mechanisms linking phthalates to ADHD. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000432619700003 |
WOS关键词 | AUTISM SPECTRUM DISORDER ; BISPHENOL-A CONCENTRATIONS ; URINARY PHTHALATE ; PREGNANT-WOMEN ; PRETERM BIRTH ; METABOLITE CONCENTRATIONS ; HORMONE CONCENTRATIONS ; TEMPORAL VARIABILITY ; MEDIATION ANALYSIS ; FETAL-GROWTH |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22372 |
专题 | 资源环境科学 |
作者单位 | 1.Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27515 USA; 2.Norwegian Inst Publ Hlth, Oslo, Norway; 3.Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Biostat, Chapel Hill, NC 27515 USA; 4.Norwegian Inst Publ Hlth, Dept Environm Exposure & Epidemiol, Div Infect Control & Environm Hlth, Oslo, Norway; 5.North Carolina State Univ, Dept Biol Sci, Raleigh, NC 27695 USA; 6.Oslo Univ Hosp, Oslo, Norway; 7.Norwegian Inst Publ Hlth, Dept Child Hlth & Dev, Div Mental & Phys Hlth, Oslo, Norway; 8.Norwegian Inst Publ Hlth, Dept Mental Disorders, Div Mental & Phys Hlth, Oslo, Norway; 9.Univ Oslo, Inst Clin Med, Oslo, Norway; 10.Duke Univ, Dept Stat Sci, Durham, NC USA; 11.Duke Univ, Global Hlth Inst, Durham, NC USA |
推荐引用方式 GB/T 7714 | Engel, Stephanie M.,Villanger, Gro D.,Nethery, Rachel C.,et al. Prenatal Phthalates, Maternal Thyroid Function, and Risk of Attention-Deficit Hyperactivity Disorder in the Norwegian Mother and Child Cohort[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2018,126(5). |
APA | Engel, Stephanie M..,Villanger, Gro D..,Nethery, Rachel C..,Thomsen, Cathrine.,Sakhi, Amrit K..,...&Aase, Heidi.(2018).Prenatal Phthalates, Maternal Thyroid Function, and Risk of Attention-Deficit Hyperactivity Disorder in the Norwegian Mother and Child Cohort.ENVIRONMENTAL HEALTH PERSPECTIVES,126(5). |
MLA | Engel, Stephanie M.,et al."Prenatal Phthalates, Maternal Thyroid Function, and Risk of Attention-Deficit Hyperactivity Disorder in the Norwegian Mother and Child Cohort".ENVIRONMENTAL HEALTH PERSPECTIVES 126.5(2018). |
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