Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP3550 |
Effects of the Endocrine-Disrupting Chemicals, Vinclozolin and Polychlorinated Biphenyls, on Physiological and Sociosexual Phenotypes in F2 Generation Sprague-Dawley Rats | |
Krishnan, Krittika1; Mittal, Nitish2; Thompson, Lindsay M.2; Rodriguez-Santiago, Mariana3; Duvauchelle, Christine L.2; Crews, David1,4; Gore, Andrea C.1,2,3 | |
2018-09-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2018 |
卷号 | 126期号:9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | BACKGROUND: Exposure to endocrine-disrupting chemicals (EDCs) during gestation influences development of the F1 generation offspring and can result in disease and dysfunction in adulthood. Limited evidence suggests consequences on the F2 generation, exposed as germ cells within the F1 fetus. These F2s provide a unique window into the programming effects of EDCs. OBJECTIVE: This study assessed intergenerational effects of EDC exposure on adult physiology and behavior in Sprague-Dawley rats. METHODS: Pregnant rats were exposed to either a polychlorinated biphenyl (PCB) mixture, Aroclor 1,221 (A1221), the fungicide vinclozolin (VIN), or the vehicle (VEH) (6% dimethylsulfoxide in sesame oil) alone. A1221 is weakly estrogenic, while VIN is antiandroQenic, enabling us to compare different classes of EDCs. The F1 male and female offspring were bred to generate the paternal- and maternal-lineage F2 generation. This F2 generation was assessed for physiological outcomes, ultrasonic vocalizations (USVs), and sexual behavior in adulthood. RESULTS: Each EDC caused phenotypic effects in a sex- and lineage-dependent manner. The most robustly affected group was the paternal-lineage males, F2 VIN paternal male descendants had increased body weight throughout the lifespan, lower concentrations of circulating estradiol, and lower adrenal and testicular indices. Both VIN and A1221 paternal-lineage males also exhibited the greatest number of changes in the characteristics of USVs in response to an opposite-sex animal and changes in sexual behaviors in a mating test. CONCLUSION: Exposure of rats to EDCs at the germ cell stage led to differences in the physiological and behavioral phenotype later in life, especially in males. This finding has implications for multigenerationd physiological and reproductive health in wildlife and humans. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000449118800010 |
WOS关键词 | 50-KHZ ULTRASONIC VOCALIZATIONS ; ANXIETY-LIKE BEHAVIORS ; FEMALE RATS ; TRANSGENERATIONAL INHERITANCE ; ANTIANDROGEN VINCLOZOLIN ; DEVELOPMENTAL EXPOSURE ; PRENATAL EXPOSURE ; SEXUAL-BEHAVIOR ; GENE-EXPRESSION ; SOCIAL-BEHAVIOR |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22369 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA; 2.Univ Texas Austin, Coll Pharm, Div Pharmacol & Toxicol, Austin, TX 78712 USA; 3.Univ Texas Austin, Inst Neurosci, Austin, TX 78712 USA; 4.Univ Texas Austin, Dept Integrat Biol, Austin, TX 78712 USA |
推荐引用方式 GB/T 7714 | Krishnan, Krittika,Mittal, Nitish,Thompson, Lindsay M.,et al. Effects of the Endocrine-Disrupting Chemicals, Vinclozolin and Polychlorinated Biphenyls, on Physiological and Sociosexual Phenotypes in F2 Generation Sprague-Dawley Rats[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2018,126(9). |
APA | Krishnan, Krittika.,Mittal, Nitish.,Thompson, Lindsay M..,Rodriguez-Santiago, Mariana.,Duvauchelle, Christine L..,...&Gore, Andrea C..(2018).Effects of the Endocrine-Disrupting Chemicals, Vinclozolin and Polychlorinated Biphenyls, on Physiological and Sociosexual Phenotypes in F2 Generation Sprague-Dawley Rats.ENVIRONMENTAL HEALTH PERSPECTIVES,126(9). |
MLA | Krishnan, Krittika,et al."Effects of the Endocrine-Disrupting Chemicals, Vinclozolin and Polychlorinated Biphenyls, on Physiological and Sociosexual Phenotypes in F2 Generation Sprague-Dawley Rats".ENVIRONMENTAL HEALTH PERSPECTIVES 126.9(2018). |
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