Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP277 |
Polychlorinated Biphenyl and Organochlorine Pesticide Concentrations in Maternal Mid-Pregnancy Serum Samples: Association with Autism Spectrum Disorder and Intellectual Disability | |
Lyall, Kristen1; Croen, Lisa. A.; Sjodin, Andreas3; Yoshida, Cathleen K.; Zerbo, Ousseny; Kharrazi, Martin1; Windham, Gayle C.1 | |
2017-03-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:3 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Background: Polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) are neurodevelopmental toxicants, but few studies have examined associations with autism spectrum disorder (ASD). Objectives: We aimed to determine whether prenatal exposure to PCBs and OCPs influences offspring risk of ASD and intellectual disability without autism (ID). Methods: We conducted a population-based case-control study among Southern California births, including children with ASD (n = 545) meeting Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV-TR) criteria and ID (n = 181), as well as general population (GP) controls (n = 418). Concentrations of 11 PCB congeners and 2 OCPs measured in banked second-trimester serum samples were compared between the diagnostic groups. Logistic regression was used to calculate crude and adjusted odds ratios (AOR) for associations with ASD, and separately for ID, compared with GP controls, by quartiles of analyte concentrations in primary analyses. Results: Geometric mean levels of several PCB congeners were higher in the ASD group than in the ID and GP groups. ASD risk was elevated for a number of PCB congeners, particularly for the highest vs. lowest quartile of PCB138/158 (AOR = 1.79; 95% CI: 1.10, 2.71) and PCB153 (AOR = 1.82; 95% CI: 1.10, 3.02), and for highest deciles of other congeners in secondary analyses. PCB138/158 was also associated with increased ID (AOR = 2.41; 95% CI: 1.18, 4.91), though no trend was suggested. OCPs were not associated with increased risk of ASD in primary analyses, whereas nonmonotonic increases in risk of ID were found with p, p' - DDE. Conclusions: Our results suggest higher levels of some organochlorine compounds during pregnancy are associated with ASD and ID. |
领域 | 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000395714400031 |
WOS关键词 | POLYBROMINATED DIPHENYL ETHERS ; IMMUNE-SYSTEM ; CHILDREN ; EXPOSURE ; NEURODEVELOPMENT ; PERSISTENT ; BRAIN ; BEHAVIORS ; CHEMICALS ; P,P' ; -DDE |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22226 |
专题 | 资源环境科学 |
作者单位 | 1.Calif Dept Publ Hlth, Environm Hlth Invest Branch, Richmond, CA USA; 2.Kaiser Permanente, Div Res, Oakland, CA USA; 3.Ctr Dis Control & Prevent, Div Lab Sci, Natl Ctr Environm Hlth, Atlanta, GA USA |
推荐引用方式 GB/T 7714 | Lyall, Kristen,Croen, Lisa. A.,Sjodin, Andreas,et al. Polychlorinated Biphenyl and Organochlorine Pesticide Concentrations in Maternal Mid-Pregnancy Serum Samples: Association with Autism Spectrum Disorder and Intellectual Disability[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(3). |
APA | Lyall, Kristen.,Croen, Lisa. A..,Sjodin, Andreas.,Yoshida, Cathleen K..,Zerbo, Ousseny.,...&Windham, Gayle C..(2017).Polychlorinated Biphenyl and Organochlorine Pesticide Concentrations in Maternal Mid-Pregnancy Serum Samples: Association with Autism Spectrum Disorder and Intellectual Disability.ENVIRONMENTAL HEALTH PERSPECTIVES,125(3). |
MLA | Lyall, Kristen,et al."Polychlorinated Biphenyl and Organochlorine Pesticide Concentrations in Maternal Mid-Pregnancy Serum Samples: Association with Autism Spectrum Disorder and Intellectual Disability".ENVIRONMENTAL HEALTH PERSPECTIVES 125.3(2017). |
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