Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP460 |
Exposure to Traffic-Related Air Pollution and Serum Inflammatory Cytokines in Children | |
Gruzieva, Olena1; Merid, Simon Kebede1; Gref, Anna1; Gajulapuri, Ashwini1; Lemonnier, Nathanael2; Ballereau, Stephane2; Gigante, Bruna1; Kere, Juha3; Auffray, Charles2; Melen, Erik1,4,5; Pershagen, Goran1,5 | |
2017-06-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:6 |
文章类型 | Article |
语种 | 英语 |
国家 | Sweden; France |
英文摘要 | BACKGROUND: Long-term exposure to ambient air pollution can lead to adverse health effects in children; however, underlying biological mechanisms are not fully understood. OBJECTIVES: We evaluated the effect of air pollution exposure during different time periods on mRNA expression as well as circulating levels of inflammatory cytokines in children. METHODS: We measured a panel of 10 inflammatory markers in peripheral blood samples from 670 8-y-old children in the Barn/Child, Allergy, Milieu, Stockholm, Epidemiology (BAMSE) birth cohort. Outdoor concentrations of nitrogen dioxide (NO2) and particulate matter (PM) with aerodynamic diameter <10 mu m (PM1] from road traffic were estimated for residential, daycare, and school addresses using dispersion modeling. Time weighted average exposures during infancy and at biosampling were linked to serum cytokine levels using linear regression analysis. Furthermore, gene expression data from 16-year-olds in BAMSE (n = 238) were used to evaluate links between air pollution exposure and expression of genes coding for the studied inflammatory markers. RESULTS: A 10 mu g/m(3) increase of NO2 exposure during infancy was associated with a 13.6% (95% confidence interval (CI): 0.8; 28.1%) increase in interleukin-6 (IL-6)levels, as well as with a 27.8% (95% CI: 4.6, 56.2%) increase in IL-10 levels, the latter limited to children with asthma. However, no clear associations were observed for current exposure. Results were similar using PM10, which showed a high correlation with NO2. The functional analysis identified several differentially expressed genes in response to air pollution exposure during infancy, including 11,10, 11,13, and INF. CONCLUSION: Our results indicate alterations in systemic inflammatory markers in 8-y-old children in relation to early-life exposure to traffic-related air pollution. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413788400016 |
WOS关键词 | DIESEL EXHAUST ; ANTIINFLAMMATORY CYTOKINES ; PARTICULATE MATTER ; OXIDATIVE STRESS ; ASTHMA ; RESPONSES ; DISEASE ; MARKERS ; ASSOCIATION ; ANTIOXIDANT |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22222 |
专题 | 资源环境科学 |
作者单位 | 1.Karolinska Inst, Inst Environm Med, Nobels Vag 13 Box 210, SE-17177 Stockholm, Sweden; 2.Univ Lyon, CNRS ENS UCBL, European Inst Syst Biol & Med, Lyon, France; 3.Karolinska Inst, Dept Biosci & Nutr, Stockholm, Sweden; 4.Sachs Childrens Hosp, Dept Paediat, Stockholm, Sweden; 5.Stockholm Cty Council, Ctr Occupat & Environm Med, Stockholm, Sweden |
推荐引用方式 GB/T 7714 | Gruzieva, Olena,Merid, Simon Kebede,Gref, Anna,et al. Exposure to Traffic-Related Air Pollution and Serum Inflammatory Cytokines in Children[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(6). |
APA | Gruzieva, Olena.,Merid, Simon Kebede.,Gref, Anna.,Gajulapuri, Ashwini.,Lemonnier, Nathanael.,...&Pershagen, Goran.(2017).Exposure to Traffic-Related Air Pollution and Serum Inflammatory Cytokines in Children.ENVIRONMENTAL HEALTH PERSPECTIVES,125(6). |
MLA | Gruzieva, Olena,et al."Exposure to Traffic-Related Air Pollution and Serum Inflammatory Cytokines in Children".ENVIRONMENTAL HEALTH PERSPECTIVES 125.6(2017). |
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