Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP1521 |
Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort | |
Yuan, Yu1,2; Xiao, Yang1,2; Feng, Wei1,2; Liu, Yiyi1,2; Yu, Yanqiu1,2; Zhou, Lue1,2; Qiu, Gaokun1,2; Wang, Hao1,2; Liu, Bing1,2; Liu, Kang1,2; Yang, Handong3; Li, Xiulou3; Min, Xinwen3; Zhang, Ce3; Xu, Chengwei3; Zhang, Xiaomin1,2; He, Meian1,2; Hu, Frank B.4,5; Pan, An6; Wu, Tangchun1,2 | |
2017-10-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:10 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA |
英文摘要 | BACKGROUND: Circulating metals from both the natural environment and pollution have been linked to cardiovascular disease. However,few prospective studies have investigated the associations between exposure to multiple metals and incident coronary heart disease (CHD). OBJECTIVES: We conducted a nested case control study in the prospective Dongfeng-Tongji cohort, to investigate the prospective association between plasma metal concentrations and incident CHD. METHODS: A total of 1,621 incident CHD cases and 1,621 controls free of major cardiovascular disease at baseline and follow-up visits were matched on age (+/- 5 years) and sex. We measured baseline fasting plasma concentrations of 23 metals and used conditional logistic regression models to estimate odds ratios (ORs) of CHI) for metal concentrations categorized according to quartiles in controls. RESULTS: Five metals (titanium, arsenic, selenium, aluminum, and barium) were significantly associated with CHD based on trend tests from single metal multivariable models adjusted for established cardiovascular risk factors. When all five were included in the same model, adjusted ORs for barium and aluminum were close to the null, whereas associations with titanium, arsenic, and selenium were similar to estimates from single-metal models, and ORs comparing extreme quartiles were 1.32 (95% CI: 1.03, 1.69; p-trend = 0.04), 1.78 (95% CI: 1.29, 2.46; p-trend = 0.001), and 0.67 (95% Cl: 0.52, 0.85; p-trend = 0.001), respectively. CONCLUSIONS: Our study suggested that incident CHD was positively associated with plasma levels of titanium and arsenic, and inversely associated with selenium. Additional research is needed to confirm these findings in other populations. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413793300019 |
WOS关键词 | SERUM TITANIUM LEVELS ; CARDIOVASCULAR-DISEASE ; WHOLE-BLOOD ; ARSENIC EXPOSURE ; REFERENCE VALUES ; SELENIUM STATUS ; TASK-FORCE ; US ADULTS ; HEALTH ; POPULATION |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22221 |
专题 | 资源环境科学 |
作者单位 | 1.Huazhong Univ Sci & Technol, Minist Educ, Key Lab Environm & Hlth, Dept Occupat & Environm Hlth, Wuhan, Hubei, Peoples R China; 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating, Wuhan, Hubei, Peoples R China; 3.Hubei Univ Med, Dept Cardiovasc Dis, Dongfeng Cent Hosp, Shiyan, Peoples R China; 4.Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA; 5.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA; 6.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan, Hubei, Peoples R China |
推荐引用方式 GB/T 7714 | Yuan, Yu,Xiao, Yang,Feng, Wei,et al. Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(10). |
APA | Yuan, Yu.,Xiao, Yang.,Feng, Wei.,Liu, Yiyi.,Yu, Yanqiu.,...&Wu, Tangchun.(2017).Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort.ENVIRONMENTAL HEALTH PERSPECTIVES,125(10). |
MLA | Yuan, Yu,et al."Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort".ENVIRONMENTAL HEALTH PERSPECTIVES 125.10(2017). |
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