Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1175/JCLI-D-15-0741.1 |
FGF-dependent metabolic control of vascular development | |
Yu, Pengchun1; Wilhelm, Kerstin2; Dubrac, Alexandre1; Tung, Joe K.1; Alves, Tiago C.3; Fang, Jennifer S.1; Xie, Yi1; Zhu, Jie4; Chen, Zehua5; De Smet, Frederik6,7; Zhang, Jiasheng1; Jin, Suk-Won1,8; Sun, Lele9; Sun, Hongye9; Kibbey, Richard G.3; Hirschi, Karen K.1; Hay, Nissim10; Carmeliet, Peter11,12; Chittenden, Thomas W.5; Eichmann, Anne1,13; Potente, Michael2; Simons, Michael1,14 | |
2017-05-11 | |
发表期刊 | NATURE
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ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2017 |
卷号 | 545期号:7653页码:224-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Germany; Belgium; South Korea; Peoples R China; France |
英文摘要 | Blood and lymphatic vasculatures are intimately involved in tissue oxygenation and fluid homeostasis maintenance. Assembly of these vascular networks involves sprouting, migration and proliferation of endothelial cells. Recent studies have suggested that changes in cellular metabolism are important to these processes(1). Although much is known about vascular endothelial growth factor (VEGF)-dependent regulation of vascular development and metabolism(2,3), little is understood about the role of fibroblast growth factors (FGFs) in this context(4). Here we identify FGF receptor (FGFR) signalling as a critical regulator of vascular development. This is achieved by FGF-dependent control of c-MYC (MYC) expression that, in turn, regulates expression of the glycolytic enzyme hexokinase 2 (HK2). A decrease in HK2 levels in the absence of FGF signalling inputs results in decreased glycolysis, leading to impaired endothelial cell proliferation and migration. Pan-endothelial-and lymphatic-specific Hk2 knockouts phenocopy blood and/or lymphatic vascular defects seen in Fgfr1/Fgfr3 double mutant mice, while HK2 overexpression partly rescues the defects caused by suppression of FGF signalling. Thus, FGF-dependent regulation of endothelial glycolysis is a pivotal process in developmental and adult vascular growth and development. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000400963800034 |
WOS关键词 | ENDOTHELIAL-CELL METABOLISM ; GENE-EXPRESSION ; GROWTH-FACTOR ; LYMPHANGIOGENESIS ; MAINTENANCE ; MECHANISMS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/20904 |
专题 | 气候变化 |
作者单位 | 1.Yale Univ, Sch Med, Yale Cardiovasc Res Ctr, 333 Cedar St, New Haven, CT 06511 USA; 2.Max Plank Inst Heart & Lung Res, Angiogenesis & Metab Lab, D-61231 Bad Nauheim, Germany; 3.Yale Univ, Sch Med, Dept Internal Med, Endocrinol Sect, 333 Cedar St, New Haven, CT 06520 USA; 4.Yale Univ, Sch Med, Dept Cellular & Mol Physiol, 333 Cedar St, New Haven, CT 06520 USA; 5.WuXi NextCODE Genom, Computat Stat & Bioinformat Grp, Adv Artificial Intelligence Res Lab, Cambridge, MA 02142 USA; 6.VIB KU Leuven, Switch Lab, B-3000 Leuven, Belgium; 7.Dana Farber Canc Inst, Ctr Mol Oncol Pathol, Boston, MA 02215 USA; 8.Gwangju Inst Sci & Technol, Sch Life Sci, Gwangju 61005, South Korea; 9.WuXi NextCODE Genom, Genom Lab, 288 Fute Zhong Rd, Shanghai 200131, Peoples R China; 10.Univ Illinois, Coll Med, Dept Biochem & Mol Genet, Chicago, IL 60607 USA; 11.Katholieke Univ Leuven, Dept Oncol, Lab Angiogenesis & Neurovasc Link, B-3000 Leuven, Belgium; 12.VIB, Vesalius Res Ctr, Lab Angiogenesis & Neurovasc Link, B-3000 Leuven, Belgium; 13.Paris Cardiovasc Res Ctr, U970, 56 Rue Leblanc, F-75015 Paris, France; 14.Yale Univ, Sch Med, Dept Cell Biol, 333 Cedar St, New Haven, CT 06520 USA |
推荐引用方式 GB/T 7714 | Yu, Pengchun,Wilhelm, Kerstin,Dubrac, Alexandre,et al. FGF-dependent metabolic control of vascular development[J]. NATURE,2017,545(7653):224-+. |
APA | Yu, Pengchun.,Wilhelm, Kerstin.,Dubrac, Alexandre.,Tung, Joe K..,Alves, Tiago C..,...&Simons, Michael.(2017).FGF-dependent metabolic control of vascular development.NATURE,545(7653),224-+. |
MLA | Yu, Pengchun,et al."FGF-dependent metabolic control of vascular development".NATURE 545.7653(2017):224-+. |
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