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In climate variability studies, lagged linear regression is frequently used to infer causality. While lagged linear regression analysis can often provide valuable information about causal relationships, lagged regression is also susceptible to overreporting significant relationships when one or more of the variables has substantial memory (autocorrelation). Granger causality analysis takes into account the memory of the data and is therefore not susceptible to this issue. A simple Monte Carlo example highlights the advantages of Granger causality, compared to traditional lagged linear regression analysis in situations with one or more highly autocorrelated variables. Differences between the two approaches are further explored in two illustrative examples applicable to large-scale climate variability studies. Given that Granger causality is straightforward to calculate, Granger causality analysis may be preferable to traditional lagged regression analysis when one or more datasets has large memory.