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DOI | 10.1038/s41467-019-12862-7 |
Regulation of T cell afferent lymphatic migration by targeting LT beta R-mediated non-classical NF kappa B signaling | |
Piao, Wenji1; Xiong, Yanbao1,2; Famulski, Konrad3; Brinkman, C. Colin1,2; Li, Lushen1,2; Toney, Nicholas1; Wagner, Chelsea1,2; Saxena, Vikas1,2; Simon, Thomas1,2; Bromberg, Jonathan S.1,2,4 | |
2019-11-01 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Canada |
英文摘要 | Lymphotoxin-beta receptor (LT beta R) signaling in lymphatic endothelial cells (LEC) regulates leukocyte afferent lymphatic transendothelial migration (TEM). The function of individual signaling pathways for different leukocyte subsets is currently unknown. Here, we show that LT beta R signals predominantly via the constitutive and ligand-driven non-classical NIK pathway. Targeting LT beta R-NIK by an LT beta R-derived decoy peptide (nciLT) suppresses the production of chemokines CCL21 and CXCL12, and enhances the expression of classical NF kappa B-driven VCAM-1 and integrin beta 4 to retain T cells on LEC and precludes T cell and dendritic cell TEM. nciLT inhibits contact hypersensitivity (CHS) at both the sensitization and elicitation stages, likely by inhibiting leukocyte migration. By contrast, targeting LT beta R-classical NF kappa B signaling during the elicitation and resolution stages attenuates CHS, possibly by promoting leukocyte egress. These findings demonstrate the importance of LT beta R signaling in leukocyte migration and LEC and lymphatic vessel function, and show that antagonist peptides may serve as lead compounds for therapeutic applications. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000440413800002 |
WOS关键词 | TUMOR-NECROSIS-FACTOR ; PERIPHERAL LYMPHOID ORGANS ; DENDRITIC CELLS ; CONTACT HYPERSENSITIVITY ; GENE-EXPRESSION ; ENDOTHELIAL-CELLS ; LYMPHOTOXIN ; RECEPTOR ; PATHWAYS ; NODES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204629 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Maryland, Ctr Vasc & Inflammatory Dis, Sch Med, Baltimore, MD 21201 USA; 2.Univ Maryland, Sch Med, Dept Surg, Baltimore, MD 21201 USA; 3.Univ Alberta, Dept Lab Med & Pathol, Heritage Med Res Ctr 250, Edmonton, AB T6G 2S2, Canada; 4.Univ Alberta, Dept Microbiol & Immunol, Sch Med, Baltimore, MD 21201 USA |
推荐引用方式 GB/T 7714 | Piao, Wenji,Xiong, Yanbao,Famulski, Konrad,et al. Regulation of T cell afferent lymphatic migration by targeting LT beta R-mediated non-classical NF kappa B signaling[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Piao, Wenji.,Xiong, Yanbao.,Famulski, Konrad.,Brinkman, C. Colin.,Li, Lushen.,...&Bromberg, Jonathan S..(2019).Regulation of T cell afferent lymphatic migration by targeting LT beta R-mediated non-classical NF kappa B signaling.NATURE COMMUNICATIONS,9. |
MLA | Piao, Wenji,et al."Regulation of T cell afferent lymphatic migration by targeting LT beta R-mediated non-classical NF kappa B signaling".NATURE COMMUNICATIONS 9(2019). |
条目包含的文件 | 条目无相关文件。 |
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