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DOI | 10.1038/s41467-019-12883-2 |
Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection | |
Song, Peixin1; Zheng, Nan2,3,4; Liu, Yong5; Tian, Chen1; Wu, Xilin2,4; Ma, Xiaohua6; Chen, Deyan2,3; Zou, Xue2,3; Wang, Guiyang1; Wang, Huanru2,3; Zhang, Yongyang1; Lu, Sufang1; Wu, Chao1; Wu, Zhiwei2,3,4 | |
2019-10-29 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | Severe Fever with Thrombocytopenia Syndrome (SFTS), an emerging infectious disease caused by a novel phlebovirus, is associated with high fatality. Therapeutic interventions are lacking and disease pathogenesis is yet to be fully elucidated. The anti-viral immune response has been reported, but humoral involvement in viral pathogenesis is poorly understood. Here we show defective serological responses to SFTSV is associated with disease fatality and a combination of B-cell and T-cell impairment contribute to disruption of anti-viral immunity. The serological profile in deceased patients is characterized by absence of specific IgG to viral nucleocapsid and glycoprotein due to failure of B-cell class switching. Expansion and impairment of antibody secretion is a signature of fatal SFTSV infection. Apoptosis of monocytes in the early stage of infection diminishes antigen-presentation by dendritic cells, impedes differentiation and function of T follicular helper cells, and contributes to failure of the virus-specific humoral response. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000442123600003 |
WOS关键词 | THROMBOCYTOPENIA SYNDROME VIRUS ; CLASS-SWITCH RECOMBINATION ; FOLLICULAR HELPER-CELLS ; REGULATORY T-CELLS ; DENDRITIC CELLS ; SEVERE FEVER ; ANTIGEN PRESENTATION ; HEMORRHAGIC-FEVER ; ANTIBODY-RESPONSE ; GERMINAL-CENTERS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204620 |
专题 | 资源环境科学 |
作者单位 | 1.Nanjing Univ, Med Sch, Nanjing Drum Tower Hosp, Dept Infect Dis, Nanjing, Jiangsu, Peoples R China; 2.Nanjing Univ, Med Sch, Ctr Publ Hlth Res, Nanjing, Jiangsu, Peoples R China; 3.Nanjing Univ, State Key Lab Analyt Chem Life Sci, Nanjing, Jiangsu, Peoples R China; 4.Nanjing Univ, Med Sch, Jiangsu Lab Mol Med, Nanjing, Jiangsu, Peoples R China; 5.Nanjing Univ, Med Sch, Nanjing Drum Tower Hosp, Dept Expt Med, Nanjing, Jiangsu, Peoples R China; 6.Y Clone BioMed Ltd, Suzhou Hitech Innovat Pk, Suzhou, Peoples R China |
推荐引用方式 GB/T 7714 | Song, Peixin,Zheng, Nan,Liu, Yong,et al. Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Song, Peixin.,Zheng, Nan.,Liu, Yong.,Tian, Chen.,Wu, Xilin.,...&Wu, Zhiwei.(2019).Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection.NATURE COMMUNICATIONS,9. |
MLA | Song, Peixin,et al."Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection".NATURE COMMUNICATIONS 9(2019). |
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