GSTDTAP  > 资源环境科学
DOI10.1038/s41467-019-12883-2
Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection
Song, Peixin1; Zheng, Nan2,3,4; Liu, Yong5; Tian, Chen1; Wu, Xilin2,4; Ma, Xiaohua6; Chen, Deyan2,3; Zou, Xue2,3; Wang, Guiyang1; Wang, Huanru2,3; Zhang, Yongyang1; Lu, Sufang1; Wu, Chao1; Wu, Zhiwei2,3,4
2019-10-29
发表期刊NATURE COMMUNICATIONS
ISSN2041-1723
出版年2018
卷号9
文章类型Article
语种英语
国家Peoples R China
英文摘要

Severe Fever with Thrombocytopenia Syndrome (SFTS), an emerging infectious disease caused by a novel phlebovirus, is associated with high fatality. Therapeutic interventions are lacking and disease pathogenesis is yet to be fully elucidated. The anti-viral immune response has been reported, but humoral involvement in viral pathogenesis is poorly understood. Here we show defective serological responses to SFTSV is associated with disease fatality and a combination of B-cell and T-cell impairment contribute to disruption of anti-viral immunity. The serological profile in deceased patients is characterized by absence of specific IgG to viral nucleocapsid and glycoprotein due to failure of B-cell class switching. Expansion and impairment of antibody secretion is a signature of fatal SFTSV infection. Apoptosis of monocytes in the early stage of infection diminishes antigen-presentation by dendritic cells, impedes differentiation and function of T follicular helper cells, and contributes to failure of the virus-specific humoral response.


领域资源环境
收录类别SCI-E
WOS记录号WOS:000442123600003
WOS关键词THROMBOCYTOPENIA SYNDROME VIRUS ; CLASS-SWITCH RECOMBINATION ; FOLLICULAR HELPER-CELLS ; REGULATORY T-CELLS ; DENDRITIC CELLS ; SEVERE FEVER ; ANTIGEN PRESENTATION ; HEMORRHAGIC-FEVER ; ANTIBODY-RESPONSE ; GERMINAL-CENTERS
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
URL查看原文
引用统计
被引频次:62[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/204620
专题资源环境科学
作者单位1.Nanjing Univ, Med Sch, Nanjing Drum Tower Hosp, Dept Infect Dis, Nanjing, Jiangsu, Peoples R China;
2.Nanjing Univ, Med Sch, Ctr Publ Hlth Res, Nanjing, Jiangsu, Peoples R China;
3.Nanjing Univ, State Key Lab Analyt Chem Life Sci, Nanjing, Jiangsu, Peoples R China;
4.Nanjing Univ, Med Sch, Jiangsu Lab Mol Med, Nanjing, Jiangsu, Peoples R China;
5.Nanjing Univ, Med Sch, Nanjing Drum Tower Hosp, Dept Expt Med, Nanjing, Jiangsu, Peoples R China;
6.Y Clone BioMed Ltd, Suzhou Hitech Innovat Pk, Suzhou, Peoples R China
推荐引用方式
GB/T 7714
Song, Peixin,Zheng, Nan,Liu, Yong,et al. Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection[J]. NATURE COMMUNICATIONS,2019,9.
APA Song, Peixin.,Zheng, Nan.,Liu, Yong.,Tian, Chen.,Wu, Xilin.,...&Wu, Zhiwei.(2019).Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection.NATURE COMMUNICATIONS,9.
MLA Song, Peixin,et al."Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection".NATURE COMMUNICATIONS 9(2019).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Song, Peixin]的文章
[Zheng, Nan]的文章
[Liu, Yong]的文章
百度学术
百度学术中相似的文章
[Song, Peixin]的文章
[Zheng, Nan]的文章
[Liu, Yong]的文章
必应学术
必应学术中相似的文章
[Song, Peixin]的文章
[Zheng, Nan]的文章
[Liu, Yong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。