Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-019-12730-4 |
Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes | |
Ait-Bouziad, Nadine1; Lv, Guohua2,3; Mahul-Mellier, Anne-Laure1; Xiao, Shifeng2,3,5; Zorludemir, Gizem1; Eliezer, David2,3; Walz, Thomas4; Lashuel, Hilal A.1 | |
2019-10-18 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland; USA; Peoples R China |
英文摘要 | The microtubule-associated protein Tau plays a central role in the pathogenesis of Alzheimer's disease. Although Tau interaction with membranes is thought to affect some of its physiological functions and its aggregation properties, the sequence determinants and the structural and functional consequences of such interactions remain poorly understood. Here, we report that the interaction of Tau with vesicles results in the formation of highly stable protein/phospholipid complexes. These complexes are toxic to primary hippocampal cultures and are detected by MC-1, an antibody recognizing pathological Tau conformations. The core of these complexes is comprised of the PHF6* and PHF6 hexapeptide motifs, the latter in a beta-strand conformation. Studies using Tau-derived peptides enabled the design of mutants that disrupt Tau interactions with phospholipids without interfering with its ability to form fibrils, thus providing powerful tools for uncoupling these processes and investigating the role of membrane interactions in regulating Tau function, aggregation and toxicity. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000416226200007 |
WOS关键词 | PAIRED HELICAL FILAMENTS ; SYNTHETIC TAU FIBRILS ; MICROTUBULE-BINDING ; REPEAT DOMAIN ; PROTEIN-TAU ; ALZHEIMERS-DISEASE ; CROSS-POLARIZATION ; EXTRACELLULAR TAU ; IN-VITRO ; MEMBRANE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204601 |
专题 | 资源环境科学 |
作者单位 | 1.Ecole Polytech Fed Lausanne, Lab Mol & Chem Biol Neurodegenerat, Stn 19, CH-1015 Lausanne, Switzerland; 2.Weill Cornell Med, Dept Biochem, 1300 York Ave, New York, NY 10021 USA; 3.Weill Cornell Med, Program Struct Biol, 1300 York Ave, New York, NY 10021 USA; 4.Rockefeller Univ, Lab Mol Electron Microscopy, 1230 York Ave, New York, NY 10065 USA; 5.Shenzhen Univ, Coll Life Sci & Oceanog, Shenzhen Key Lab Marine Biotechnol & Ecol, Shenzhen 518060, Peoples R China |
推荐引用方式 GB/T 7714 | Ait-Bouziad, Nadine,Lv, Guohua,Mahul-Mellier, Anne-Laure,et al. Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Ait-Bouziad, Nadine.,Lv, Guohua.,Mahul-Mellier, Anne-Laure.,Xiao, Shifeng.,Zorludemir, Gizem.,...&Lashuel, Hilal A..(2019).Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes.NATURE COMMUNICATIONS,8. |
MLA | Ait-Bouziad, Nadine,et al."Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes".NATURE COMMUNICATIONS 8(2019). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论