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DOI | 10.1038/s41467-019-12539-1 |
A method to identify trace sulfated IgG N-glycans as biomarkers for rheumatoid arthritis | |
Wang, Jing-Rong1,2; Gao, Wei-Na1,2; Grimm, Rudolf3; Jiang, Shibo4,5,6; Liang, Yong1,7; Ye, Hua8; Li, Zhan-Guo8; Yau, Lee-Fong1,2; Huang, Hao1,2; Liu, Ju9; Jiang, Min9; Meng, Qiong1,2; Tong, Tian-Tian1,2; Huang, Hai-Hui7; Lee, Stephanie10; Zeng, Xing11; Liu, Liang1; Jiang, Zhi-Hong1,2 | |
2019-10-14 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA |
英文摘要 | N-linked glycans on immunoglobulin G (IgG) have been associated with pathogenesis of diseases and the therapeutic functions of antibody-based drugs; however, low-abundance species are difficult to detect. Here we show a glycomic approach to detect these species on human IgGs using a specialized microfluidic chip. We discover 20 sulfated and 4 acetylated N-glycans on IgGs. Using multiple reaction monitoring method, we precisely quantify these previously undetected low-abundance, trace and even ultra-trace N-glycans. From 277 patients with rheumatoid arthritis (RA) and 141 healthy individuals, we also identify N-glycan biomarkers for the classification of both rheumatoid factor (RF)-positive and negative RA patients, as well as anti-citrullinated protein antibodies (ACPA)-positive and negative RA patients. This approach may identify N-glycosylation-associated biomarkers for other autoimmune and infectious diseases and lead to the exploration of promising glycoforms for antibody therapeutics. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000411317800007 |
WOS关键词 | LINKED CARBOHYDRATE CHAINS ; MASS-SPECTROMETRY ; TITANIUM-DIOXIDE ; HUMAN SERUM ; PORCINE THYROGLOBULIN ; DISEASE-ACTIVITY ; SYNOVIAL-FLUID ; GLYCOSYLATION ; GLYCOPEPTIDES ; ENRICHMENT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204594 |
专题 | 资源环境科学 |
作者单位 | 1.Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Ave Wai Long, Taipa, Macau, Peoples R China; 2.Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, Ave Wai Long, Taipa, Macau, Peoples R China; 3.Agilent Technol, 5301 Stevens Creek Blvd, Santa Clara, CA 95051 USA; 4.Fudan Univ, Basic Med Coll, Key Lab Med Mol Virol, Minist Educ, Shanghai 200032, Peoples R China; 5.Fudan Univ, Basic Med Coll, Key Lab Med Mol Virol, Minist Hlth, Shanghai 200032, Peoples R China; 6.New York Blood Ctr, Lindsley F Kimball Res Inst, New York, NY 10065 USA; 7.Macau Univ Sci & Technol, Fac Informat Technol, Ave Wai Long, Taipa, Macao, Peoples R China; 8.Peking Univ, Dept Rheumatol & Immunol, Peoples Hosp, 11 Xizhimen South St, Beijing 100044, Peoples R China; 9.Jiujiang First Peoples Hosp, Div Rheumatol, Taling North Rd 48, Jiujiang 332000, Peoples R China; 10.Agilent Technol Hong Kong Ltd, Suite 2603,26-F,AXA Tower,Landmark East, Kwun Tong, Hong Kong, Peoples R China; 11.Guangdong Prov Hosp Chinese Med, Dade Rd 111, Guangzhou 510120, Guangdong, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Jing-Rong,Gao, Wei-Na,Grimm, Rudolf,et al. A method to identify trace sulfated IgG N-glycans as biomarkers for rheumatoid arthritis[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Wang, Jing-Rong.,Gao, Wei-Na.,Grimm, Rudolf.,Jiang, Shibo.,Liang, Yong.,...&Jiang, Zhi-Hong.(2019).A method to identify trace sulfated IgG N-glycans as biomarkers for rheumatoid arthritis.NATURE COMMUNICATIONS,8. |
MLA | Wang, Jing-Rong,et al."A method to identify trace sulfated IgG N-glycans as biomarkers for rheumatoid arthritis".NATURE COMMUNICATIONS 8(2019). |
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