Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-019-12469-y |
Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche | |
Yang, Ting-Lin B.1,2; Chen, Qijun1; Deng, Jennifer T.1; Jagannathan, Geetha; Tobias, John W.3; Schultz, David C.4; Wang, Shan5; Lengner, Christopher J.5; Rustgi, Anil K.6; Lynch, John P.6; Johnson, F. Brad1,2,7 | |
2019-10-09 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Critical telomere shortening (for example, secondary to partial telomerase deficiency in the rare disease dyskeratosis congenita) causes tissue pathology, but underlying mechanisms are not fully understood. Mice lacking telomerase (for example, mTR -/- telomerase RNA template mutants) provide a model for investigating pathogenesis. In such mice, after several generations of telomerase deficiency telomeres shorten to the point of uncapping, causing defects most pronounced in high-turnover tissues including intestinal epithelium. Here we show that late-generation mTR -/- mutants experience marked downregulation of Wnt pathway genes in intestinal crypt epithelia, including crypt base columnar stem cells and Paneth cells, and in underlying stroma. The importance of these changes was revealed by rescue of crypt apoptosis and Wnt pathway gene expression upon treatment with Wnt pathway agonists. Rescue was associated with reduced telomere-dysfunction-induced foci and anaphase bridges, indicating improved telomere capping. Thus a mutually reinforcing feedback loop exists between telomere capping and Wnt signalling, and telomere capping can be impacted by extracellular cues in a fashion independent of telomerase. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000396402500001 |
WOS关键词 | WNT/BETA-CATENIN ; REVERSE-TRANSCRIPTASE ; ULCERATIVE-COLITIS ; LITHIUM TREATMENT ; BIPOLAR DISORDER ; IN-VIVO ; EXPRESSION ; CANCER ; SENESCENCE ; P53 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204584 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA; 2.Univ Penn, Cell & Mol Biol Program, Biomed Grad Studies, Philadelphia, PA 19104 USA; 3.Univ Penn, Perelman Sch Med, Penn Mol Profiling Ctr, Philadelphia, PA 19104 USA; 4.Univ Penn, Wistar Inst, Philadelphia, PA 19104 USA; 5.Univ Penn, Sch Vet Med, Dept Anim Biol, Philadelphia, PA 19104 USA; 6.Univ Penn, Perelman Sch Med, Div Gastroenterol, Dept Med, Philadelphia, PA 19104 USA; 7.Univ Penn, Inst Aging, Philadelphia, PA 19104 USA |
推荐引用方式 GB/T 7714 | Yang, Ting-Lin B.,Chen, Qijun,Deng, Jennifer T.,et al. Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Yang, Ting-Lin B..,Chen, Qijun.,Deng, Jennifer T..,Jagannathan, Geetha.,Tobias, John W..,...&Johnson, F. Brad.(2019).Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche.NATURE COMMUNICATIONS,8. |
MLA | Yang, Ting-Lin B.,et al."Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche".NATURE COMMUNICATIONS 8(2019). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论