Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-019-12541-7 |
The brain is required for normal muscle and nerve patterning during early Xenopus development | |
Herrera-Rincon, Celia1,2; Pai, Vaibhav P.1,2; Moran, Kristine M.1,2; Lemire, Joan M.1,2; Levin, Michael1,2 | |
2019-10-08 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Possible roles of brain-derived signals in the regulation of embryogenesis are unknown. Here we use an amputation assay in Xenopus laevis to show that absence of brain alters subsequent muscle and peripheral nerve patterning during early development. The muscle phenotype can be rescued by an antagonist of muscarinic acetylcholine receptors. The observed defects occur at considerable distances from the head, suggesting that the brain provides long-range cues for other tissue systems during development. The presence of brain also protects embryos from otherwise-teratogenic agents. Overexpression of a hyperpolarization-activated cyclic nucleotide-gated ion channel rescues the muscle phenotype and the neural mispatterning that occur in brainless embryos, even when expressed far from the muscle or neural cells that mispattern. We identify a previously undescribed developmental role for the brain and reveal a non-local input into the control of early morphogenesis that is mediated by neurotransmitters and ion channel activity. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000411646400001 |
WOS关键词 | REGULATORY FACTOR GENES ; LIMB REGENERATION ; LAEVIS EMBRYOS ; SPINAL-CORD ; LONG-RANGE ; CELLS ; EXPRESSION ; ZEBRAFISH ; CHANNELS ; AXOLOTL |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204581 |
专题 | 资源环境科学 |
作者单位 | 1.Tufts Univ, Dept Biol, 200 Boston Ave,Suite 4600, Medford, MA 02155 USA; 2.Tufts Univ, Allen Discovery Ctr, 200 Boston Ave,Suite 4600, Medford, MA 02155 USA |
推荐引用方式 GB/T 7714 | Herrera-Rincon, Celia,Pai, Vaibhav P.,Moran, Kristine M.,et al. The brain is required for normal muscle and nerve patterning during early Xenopus development[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Herrera-Rincon, Celia,Pai, Vaibhav P.,Moran, Kristine M.,Lemire, Joan M.,&Levin, Michael.(2019).The brain is required for normal muscle and nerve patterning during early Xenopus development.NATURE COMMUNICATIONS,8. |
MLA | Herrera-Rincon, Celia,et al."The brain is required for normal muscle and nerve patterning during early Xenopus development".NATURE COMMUNICATIONS 8(2019). |
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