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DOI | 10.1038/s41467-019-12396-y |
RNA editing derived epitopes function as cancer antigens to elicit immune responses | |
Zhang, Minying1; Fritsche, Jens2; Roszik, Jason1; Williams, Leila J.1; Peng, Xinxin3; Chiu, Yulun3; Tsou, Chih-Chiang7; Hoffgaard, Franziska2; Goldfinger, Valentina2; Schoor, Oliver2; Talukder, Amjad1; Forget, Marie A.1; Haymaker, Cara1; Bernatchez, Chantale1; Han, Leng4; Tsang, Yiu-Huen5; Kong, Kathleen5; Xu, Xiaoyan3,6; Scott, Kenneth L.5; Singh-Jasuja, Harpreet2,7; Lizee, Greg1; Liang, Han3,8; Weinschenk, Toni2,7; Mills, Gordon B.8; Hwu, Patrick1 | |
2019-10-07 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Germany; Peoples R China |
英文摘要 | In addition to genomic mutations, RNA editing is another major mechanism creating sequence variations in proteins by introducing nucleotide changes in mRNA sequences. Deregulated RNA editing contributes to different types of human diseases, including cancers. Here we report that peptides generated as a consequence of RNA editing are indeed naturally presented by human leukocyte antigen (HLA) molecules. We provide evidence that effector CD8(+) T cells specific for edited peptides derived from cyclin I are present in human tumours and attack tumour cells that are presenting these epitopes. We show that subpopulations of cancer patients have increased peptide levels and that levels of edited RNA correlate with peptide copy numbers. These findings demonstrate that RNA editing extends the classes of HLA presented self-antigens and that these antigens can be recognised by the immune system. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000445561900005 |
WOS关键词 | MASS-SPECTROMETRY ; T-LYMPHOCYTES ; PROTEOMICS EXPERIMENTS ; METASTATIC MELANOMA ; CELLS ; IMMUNOTHERAPY ; MUTATIONS ; LANDSCAPE ; PEPTIDES ; DATABASE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204579 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Texas MD Anderson Canc Ctr, Dept Melanoma Med Oncol, 7455 Fannin St,Unit 904, Houston, TX 77054 USA; 2.Immat Biotechnol, Paul Ehrlich Str 15, D-72076 Tubingen, Germany; 3.Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, POB 301402, Houston, TX 77230 USA; 4.Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Biochem & Mol Biol, 6431 Fannin St MSB 6-200, Houston, TX 77030 USA; 5.Baylor Coll Med, Dept Mol & Human Genet, One Baylor Plaza,BCM225, Houston, TX 77030 USA; 6.China Med Univ, Coll Basic Med, Dept Pathophysiol, 77 Pune Rd, Shenyang 110122, Liaoning, Peoples R China; 7.Immatics US, 2130W Holcombe Blvd, Houston, TX 77030 USA; 8.Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, 1515 Holcombe Blvd, Houston, TX 77230 USA |
推荐引用方式 GB/T 7714 | Zhang, Minying,Fritsche, Jens,Roszik, Jason,et al. RNA editing derived epitopes function as cancer antigens to elicit immune responses[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Zhang, Minying.,Fritsche, Jens.,Roszik, Jason.,Williams, Leila J..,Peng, Xinxin.,...&Hwu, Patrick.(2019).RNA editing derived epitopes function as cancer antigens to elicit immune responses.NATURE COMMUNICATIONS,9. |
MLA | Zhang, Minying,et al."RNA editing derived epitopes function as cancer antigens to elicit immune responses".NATURE COMMUNICATIONS 9(2019). |
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