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DOI | 10.1038/s41467-019-12111-x |
High-resolution acoustophoretic 3D cell patterning to construct functional collateral cylindroids for ischemia therapy | |
Kang, Byungjun1; Shin, Jisoo2; Park, Hyun-Ji2; Rhyou, Chanryeol1; Kang, Donyoung1; Lee, Shin-Jeong3,4; Yoon, Young-sup3,4; Cho, Seung-Woo2,5; Lee, Hyungsuk1 | |
2019-09-27 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | South Korea; USA |
英文摘要 | The fabrication of functional tissues is essential for clinical applications such as disease treatment and drug discovery. Recent studies have revealed that the mechanical environments of tissues, determined by geometric cell patterns, material composition, or mechanical properties, play critical roles in ensuring proper tissue function. Here, we propose an acoustophoretic technique using surface acoustic waves to fabricate therapeutic vascular tissue containing a three-dimensional collateral distribution of vessels. Co-aligned human umbilical vein endothelial cells and human adipose stem cells that are arranged in a biodegradable catechol-conjugated hyaluronic acid hydrogel exhibit enhanced cell-cell contacts, gene expression, and secretion of angiogenic and anti-inflammatory paracrine factors. The therapeutic effects of the fabricated vessel constructs are demonstrated in experiments using an ischemia mouse model by exhibiting the remarkable recovery of damaged tissue. Our study can be referenced to fabricate various types of artificial tissues that mimic the original functions as well as structures. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000453830200001 |
WOS关键词 | SURFACE ACOUSTIC-WAVES ; MESENCHYMAL STEM-CELLS ; TISSUE ; HYDROGELS ; ANGIOGENESIS ; IMPROVEMENT ; EXPRESSION ; STRATEGIES ; SECRETION ; SCAFFOLDS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204566 |
专题 | 资源环境科学 |
作者单位 | 1.Yonsei Univ, Sch Mech Engn, Seoul 03722, South Korea; 2.Yonsei Univ, Dept Biotechnol, Seoul 03722, South Korea; 3.Emory Univ, Sch Med, Dept Med, Div Cardiol, Atlanta, GA 30322 USA; 4.Yonsei Univ, Coll Med, Severance Biomed Sci Inst, Seoul 03722, South Korea; 5.Inst for Basic Sci Korea, Ctr Nanomed, Seoul 03722, South Korea |
推荐引用方式 GB/T 7714 | Kang, Byungjun,Shin, Jisoo,Park, Hyun-Ji,et al. High-resolution acoustophoretic 3D cell patterning to construct functional collateral cylindroids for ischemia therapy[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Kang, Byungjun.,Shin, Jisoo.,Park, Hyun-Ji.,Rhyou, Chanryeol.,Kang, Donyoung.,...&Lee, Hyungsuk.(2019).High-resolution acoustophoretic 3D cell patterning to construct functional collateral cylindroids for ischemia therapy.NATURE COMMUNICATIONS,9. |
MLA | Kang, Byungjun,et al."High-resolution acoustophoretic 3D cell patterning to construct functional collateral cylindroids for ischemia therapy".NATURE COMMUNICATIONS 9(2019). |
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