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DOI | 10.1038/s41467-019-12195-5 |
Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish | |
Wehner, Daniel1; Tsarouchas, Themistoklis M.1; Michael, Andria1; Haase, Christa2; Weidinger, Gilbert3; Reimer, Michell M.4; Becker, Thomas1; Becker, Catherina G.1 | |
2019-09-17 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Scotland; Germany |
英文摘要 | The inhibitory extracellular matrix in a spinal lesion site is a major impediment to axonal regeneration in mammals. In contrast, the extracellular matrix in zebrafish allows substantial axon re-growth, leading to recovery of movement. However, little is known about regulation and composition of the growth-promoting extracellular matrix. Here we demonstrate that activity of the Wnt/beta-catenin pathway in fibroblast-like cells in the lesion site is pivotal for axon re-growth and functional recovery. Wnt/beta-catenin signaling induces expression of col12a1a/b and deposition of Collagen XII, which is necessary for axons to actively navigate the non-neural lesion site environment. Overexpression of col12a1a rescues the effects of Wnt/beta-catenin pathway inhibition and is sufficient to accelerate regeneration. We demonstrate that in a vertebrate of high regenerative capacity, Wnt/beta-catenin signaling controls the composition of the lesion site extracellular matrix and we identify Collagen XII as a promoter of axonal regeneration. These findings imply that the Wnt/beta-catenin pathway and Collagen XII may be targets for extracellular matrix manipulations in non-regenerating species. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000406257200003 |
WOS关键词 | BETA-CATENIN ACTIVITY ; EXTRACELLULAR-MATRIX ; IN-VIVO ; LH3 GLYCOSYLTRANSFERASE ; AXONAL REGENERATION ; CELLS ; EXPRESSION ; TRANSCRIPTION ; REVEALS ; GROWTH |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204542 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Edinburgh, Ctr Neuroregenerat, Chancellors Bldg,49 Little France Crescent, Edinburgh EH16 4SB, Midlothian, Scotland; 2.Tech Univ Dresden, Inst Immunol, Fetscherstr 74, D-01307 Dresden, Germany; 3.Univ Ulm, Inst Biochem & Mol Biol, Albert Einstein Allee 11, D-89081 Ulm, Germany; 4.Tech Univ Dresden, DFG Ctr Regenerat Therapies Dresden, Cluster Excellence TU Dresden, Fetscherstr 105, D-01307 Dresden, Germany |
推荐引用方式 GB/T 7714 | Wehner, Daniel,Tsarouchas, Themistoklis M.,Michael, Andria,et al. Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Wehner, Daniel.,Tsarouchas, Themistoklis M..,Michael, Andria.,Haase, Christa.,Weidinger, Gilbert.,...&Becker, Catherina G..(2019).Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish.NATURE COMMUNICATIONS,8. |
MLA | Wehner, Daniel,et al."Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish".NATURE COMMUNICATIONS 8(2019). |
条目包含的文件 | 条目无相关文件。 |
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