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DOI | 10.1038/s41467-019-12013-y |
Uncovering hidden brain state dynamics that regulate performance and decision-making during cognition | |
Taghia, Jalil1; Cai, Weidong1; Ryali, Srikanth1; Kochalka, John1; Nicholas, Jonathan1; Chen, Tianwen1; Menon, Vinod1,2,3 | |
2019-09-11 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Human cognition is influenced not only by external task demands but also latent mental processes and brain states that change over time. Here, we use novel Bayesian switching dynamical systems algorithm to identify hidden brain states and determine that these states are only weakly aligned with external task conditions. We compute state transition probabilities and demonstrate how dynamic transitions between hidden states allow flexible reconfiguration of functional brain circuits. Crucially, we identify latent transient brain states and dynamic functional circuits that are optimal for cognition and show that failure to engage these states in a timely manner is associated with poorer task performance and weaker decision-making dynamics. We replicate findings in a large sample (N = 122) and reveal a robust link between cognition and flexible latent brain state dynamics. Our study demonstrates the power of switching dynamical systems models for investigating hidden dynamic brain states and functional interactions underlying human cognition. |
领域 | 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000436540700023 |
WOS关键词 | WORKING-MEMORY ; FUNCTIONAL CONNECTIVITY ; PREFRONTAL CORTEX ; FRONTAL-CORTEX ; NETWORKS ; FMRI ; MODEL ; RECONFIGURATION ; RELIABILITY ; NEURONS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204534 |
专题 | 资源环境科学 |
作者单位 | 1.Stanford Univ, Dept Psychiat & Behav Sci, Sch Med, Stanford, CA 94305 USA; 2.Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA; 3.Stanford Univ, Stanford Neurosci Inst, Sch Med, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Taghia, Jalil,Cai, Weidong,Ryali, Srikanth,et al. Uncovering hidden brain state dynamics that regulate performance and decision-making during cognition[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Taghia, Jalil.,Cai, Weidong.,Ryali, Srikanth.,Kochalka, John.,Nicholas, Jonathan.,...&Menon, Vinod.(2019).Uncovering hidden brain state dynamics that regulate performance and decision-making during cognition.NATURE COMMUNICATIONS,9. |
MLA | Taghia, Jalil,et al."Uncovering hidden brain state dynamics that regulate performance and decision-making during cognition".NATURE COMMUNICATIONS 9(2019). |
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