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DOI | 10.1038/s41467-019-11755-z |
Cell division orientation is coupled to cell-cell adhesion by the E-cadherin/LGN complex | |
Gloerich, Martijn1,3; Bianchini, Julie M.1; Siemers, Kathleen A.1; Cohen, Daniel J.1; Nelson, W. James1,2 | |
2019-08-22 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Netherlands |
英文摘要 | Both cell-cell adhesion and oriented cell division play prominent roles in establishing tissue architecture, but it is unclear how they might be coordinated. Here, we demonstrate that the cell-cell adhesion protein E-cadherin functions as an instructive cue for cell division orientation. This is mediated by the evolutionarily conserved LGN/NuMA complex, which regulates cortical attachments of astral spindle microtubules. We show that LGN, which adopts a three-dimensional structure similar to cadherin-bound catenins, binds directly to the E-cadherin cytosolic tail and thereby localizes at cell-cell adhesions. On mitotic entry, NuMA is released from the nucleus and competes LGN from E-cadherin to locally form the LGN/NuMA complex. This mediates the stabilization of cortical associations of astral microtubules at cell-cell adhesions to orient the mitotic spindle. Our results show how E-cadherin instructs the assembly of the LGN/NuMA complex at cell-cell contacts, and define a mechanism that couples cell division orientation to intercellular adhesion. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000391062900001 |
WOS关键词 | SPINDLE ORIENTATION ; ADHERENS JUNCTIONS ; ASYMMETRIC DIVISION ; CATENIN ; PROTEINS ; POLARITY ; NUMA ; LGN ; MOLECULES ; DYNEIN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204506 |
专题 | 资源环境科学 |
作者单位 | 1.Stanford Univ, Dept Biol, Stanford, CA 94305 USA; 2.Stanford Univ, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA; 3.Univ Med Ctr Utrecht, Ctr Mol Med, Mol Canc Res, Univ Weg 100, NL-3584CG Utrecht, Netherlands |
推荐引用方式 GB/T 7714 | Gloerich, Martijn,Bianchini, Julie M.,Siemers, Kathleen A.,et al. Cell division orientation is coupled to cell-cell adhesion by the E-cadherin/LGN complex[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Gloerich, Martijn,Bianchini, Julie M.,Siemers, Kathleen A.,Cohen, Daniel J.,&Nelson, W. James.(2019).Cell division orientation is coupled to cell-cell adhesion by the E-cadherin/LGN complex.NATURE COMMUNICATIONS,8. |
MLA | Gloerich, Martijn,et al."Cell division orientation is coupled to cell-cell adhesion by the E-cadherin/LGN complex".NATURE COMMUNICATIONS 8(2019). |
条目包含的文件 | 条目无相关文件。 |
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