Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells

doi:10.1038/s41467-019-11387-3

GSTDTAP > 资源环境科学

DOI	10.1038/s41467-019-11387-3
	Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells
	Diaz-Munoz, Manuel D.1,2; Kiselev, Vladimir Yu.3,7; Le Novere, Nicolas 3; Curk, Tomaz 4; Ule, Jernej 5,6; Turner, Martin 1
	2019-08-20
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
出版年	2017
卷号	8
文章类型	Article
语种	英语
国家	England; France; Slovenia
英文摘要	Post-transcriptional regulation of cellular mRNA is essential for protein synthesis. Here we describe the importance of mRNA translational repression and mRNA subcellular location for protein expression during B lymphocyte activation and the DNA damage response. Cytoplasmic RNA granules are formed upon cell activation with mitogens, including stress granules that contain the RNA binding protein Tia1. Tia1 binds to a subset of transcripts involved in cell stress, including p53 mRNA, and controls translational silencing and RNA granule localization. DNA damage promotes mRNA relocation and translation in part due to dissociation of Tia1 from its mRNA targets. Upon DNA damage, p53 mRNA is released from stress granules and associates with polyribosomes to increase protein synthesis in a CAP-independent manner. Global analysis of cellular mRNA abundance and translation indicates that this is an extended ATM-dependent mechanism to increase protein expression of key modulators of the DNA damage response.
领域	资源环境
收录类别	SCI-E
WOS记录号	WOS:000410709900006
WOS关键词	CLASS SWITCH RECOMBINATION ; MAMMALIAN STRESS GRANULES ; MHC CLASS-I ; DNA-DAMAGE ; GERMINAL-CENTER ; V(D)J RECOMBINATION ; GENOMIC STABILITY ; GENOTOXIC STRESS ; ATAXIA-TELANGIECTASIA ; DEFICIENT LYMPHOCYTES
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/204502
专题	资源环境科学
作者单位	1.Babraham Inst, Lab Lymphocyte Signalling & Dev, Cambridge CB22 3AT, England; 2.INSERM, UMR1043, CNRS, Ctr Physiopathol Toulouse Purpan,U5282, F-31300 Toulouse, France; 3.Babraham Inst, Lab Signalling, Cambridge CB22 3AT, England; 4.Univ Ljubljana, Fac Comp & Informat Sci, Ljubljana, Slovenia; 5.UCL Inst Neurol, Dept Mol Neurosci, Queen Sq, London WC1N 3BG, England; 6.Crick Inst, 1 Midland Rd, London NW1 1AT, England; 7.Wellcome Trust Sanger Inst, Wellcome Trust Genome Campus, Cambridge CB10 1SA, England
推荐引用方式 GB/T 7714	Diaz-Munoz, Manuel D.,Kiselev, Vladimir Yu.,Le Novere, Nicolas,et al. Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells[J]. NATURE COMMUNICATIONS,2019,8.
APA	Diaz-Munoz, Manuel D.,Kiselev, Vladimir Yu.,Le Novere, Nicolas,Curk, Tomaz,Ule, Jernej,&Turner, Martin.(2019).Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells.NATURE COMMUNICATIONS,8.
MLA	Diaz-Munoz, Manuel D.,et al."Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells".NATURE COMMUNICATIONS 8(2019).