Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-019-11685-w |
Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex | |
Zhou, Haocheng1,2,3; Zhang, Qiaosheng3; Martinez, Erik3; Dale, Jahrane3; Hu, Sile4; Zhang, Eric3; Liu, Kevin3; Huang, Dong1,2; Yang, Guang3,5; Chen, Zhe4,5; Wang, Jing3,5 | |
2019-08-19 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA |
英文摘要 | Chronic pain is known to induce an amplified aversive reaction to peripheral nociceptive inputs. This enhanced affective response constitutes a key pathologic feature of chronic pain syndromes such as fibromyalgia. However, the neural mechanisms that underlie this important aspect of pain processing remain poorly understood, hindering the development of treatments. Here, we show that a single dose of ketamine can produce a persistent reduction in the aversive response to noxious stimuli in rodent chronic pain models, long after the termination of its anti-nociceptive effects. Furthermore, we demonstrated that this anti-aversive property is mediated by prolonged suppression of the hyperactivity of neurons in the anterior cingulate cortex (ACC), a brain region well known to regulate pain affect. Therefore, our results indicate that it is feasible to dissociate the affective from the sensory component of pain, and demonstrate the potential for low-dose ketamine to be an important therapy for chronic pain syndromes. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000444554800008 |
WOS关键词 | DEPRESSION-LIKE BEHAVIORS ; CHRONIC NEUROPATHIC PAIN ; FORCED SWIMMING TEST ; SOMATOSENSORY CORTEX ; INTRAVENOUS KETAMINE ; NOCICEPTIVE NEURONS ; PREFRONTAL CORTEX ; RAT HIPPOCAMPUS ; AMPA RECEPTORS ; DOUBLE-BLIND |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204501 |
专题 | 资源环境科学 |
作者单位 | 1.Cent S Univ, Xiangya Hosp 3, Dept Pain, Changsha 410013, Hunan, Peoples R China; 2.Cent S Univ, Inst Pain Med, Changsha 410013, Hunan, Peoples R China; 3.NYU, Sch Med, Dept Anesthesiol Perioperat Care & Pain Med, New York, NY 10016 USA; 4.NYU, Sch Med, Dept Psychiat, New York, NY 10016 USA; 5.NYU, Sch Med, Dept Neurosci & Physiol, New York, NY 10016 USA |
推荐引用方式 GB/T 7714 | Zhou, Haocheng,Zhang, Qiaosheng,Martinez, Erik,et al. Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Zhou, Haocheng.,Zhang, Qiaosheng.,Martinez, Erik.,Dale, Jahrane.,Hu, Sile.,...&Wang, Jing.(2019).Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex.NATURE COMMUNICATIONS,9. |
MLA | Zhou, Haocheng,et al."Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex".NATURE COMMUNICATIONS 9(2019). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论