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DOI | 10.1038/s41467-019-11404-5 |
Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling | |
Niepel, Mario1; 39;ayan, Avi2 | |
2019-08-08 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | More effective use of targeted anti-cancer drugs depends on elucidating the connection between the molecular states induced by drug treatment and the cellular phenotypes controlled by these states, such as cytostasis and death. This is particularly true when mutation of a single gene is inadequate as a predictor of drug response. The current paper describes a data set of similar to 600 drug cell line pairs collected as part of the NIH LINCS Program (http://www.lincsproject.org/) in which molecular data ( reduced dimensionality transcript L1000 profiles) were recorded across dose and time in parallel with phenotypic data on cellular cytostasis and cytotoxicity. We report that transcriptional and phenotypic responses correlate with each other in general, but whereas inhibitors of chaperones and cell cycle kinases induce similar transcriptional changes across cell lines, changes induced by drugs that inhibit intra-cellular signaling kinases are cell-type specific. In some drug/cell line pairs significant changes in transcription are observed without a change in cell growth or survival; analysis of such pairs identifies drug equivalence classes and, in one case, synergistic drug interactions. In this case, synergy involves cell-type specific suppression of an adaptive drug response. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413894100008 |
WOS关键词 | COMPREHENSIVE MOLECULAR PORTRAITS ; GENE-EXPRESSION SIGNATURES ; BREAST-CANCER ; LUNG-CANCER ; METASTATIC MELANOMA ; INHIBITION ; SURVIVAL ; SENSITIVITY ; DABRAFENIB ; RESISTANCE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
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文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204491 |
专题 | 资源环境科学 |
作者单位 | 1.Harvard Med Sch, Dept Syst Biol, Lab Syst Pharmacol, HMS LINCS Ctr, Boston, MA 02115 USA; 2.Icahn Sch Med Mt Sinai, LINCS Data Coordinat & Integrat Ctr BD2K, Dept Pharmacol Sci, One Gustave L Levy Pl,Box 1603, New York, NY 10029 USA; 3.Univ Calif Santa Cruz, UC Santa Cruz Genom Inst, Santa Cruz, CA 95064 USA; 4.Broad Inst MIT & Harvard Univ, Cambridge, MA 02142 USA; 5.Dana Farber Canc Inst, Boston, MA 02115 USA; 6.Howard Hughes Med Inst, Chevy Chase, MD 20815 USA |
推荐引用方式 GB/T 7714 | Niepel, Mario,39;ayan, Avi. Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Niepel, Mario,&39;ayan, Avi.(2019).Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling.NATURE COMMUNICATIONS,8. |
MLA | Niepel, Mario,et al."Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling".NATURE COMMUNICATIONS 8(2019). |
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