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DOI | 10.1038/s41467-019-11065-4 |
Mitochondrial mutations drive prostate cancer aggression | |
Hopkins, Julia F.1; Sabelnykova, Veronica Y.1; Weischenfeldt, Joachim2,3,4; Simon, Ronald5; Aguiar, Jennifer A.1; Alkallas, Rached1; Heisler, Lawrence E.1; Zhang, Junyan6; Watson, John D.1; Chua, Melvin L. K.6; Fraser, Michael6; Favero, Francesco; Lawerenz, Chris7; Plass, Christoph8; Sauter, Guido5; McPherson, John D.9; van der Kwast, Theodorus10; Korbel, Jan2,3; Schlomm, Thorsten11; Bristow, Robert G.6,12,13; Boutros, Paul C.1,12,14 | |
2019-08-05 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Canada; Germany; Denmark |
英文摘要 | Nuclear mutations are well known to drive tumor incidence, aggression and response to therapy. By contrast, the frequency and roles of mutations in the maternally inherited mitochondrial genome are poorly understood. Here we sequence the mitochondrial genomes of 384 localized prostate cancer patients, and identify a median of one mitochondrial single-nucleotide variant (mtSNV) per patient. Some of these mtSNVs occur in recurrent mutational hotspots and associate with aggressive disease. Younger patients have fewer mtSNVs than those who diagnosed at an older age. We demonstrate strong links between mitochondrial and nuclear mutational profiles, with co-occurrence between specific mutations. For example, certain control region mtSNVs co-occur with gain of the MYC oncogene, and these mutations are jointly associated with patient survival. These data demonstrate frequent mitochondrial mutation in prostate cancer, and suggest interplay between nuclear and mitochondrial mutational profiles in prostate cancer. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000411526700001 |
WOS关键词 | POINT MUTATIONS ; DNA DELETION ; GENOME ; IDENTIFICATION ; HETEROGENEITY ; HETEROPLASMY ; PREDICTION ; LANDSCAPE ; ALIGNMENT ; VARIANTS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204483 |
专题 | 资源环境科学 |
作者单位 | 1.Ontario Inst Canc Res, Informat & Biocomp Program, Toronto, ON M5G 0A3, Canada; 2.European Mol Biol Lab, Genome Biol Unit, D-69120 Heidelberg, Germany; 3.Biotech Res & Innovat Ctr, DK-2200 Copenhagen, Denmark; 4.Finsen Lab, DK-2200 Copenhagen, Denmark; 5.Univ Med Ctr Hamburg Eppendorf, Inst Pathol, D-20246 Hamburg, Germany; 6.Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5G 1L7, Canada; 7.German Canc Res Ctr, Div Theoret Bioinformat, D-69120 Heidelberg, Germany; 8.German Canc Res Ctr, Div Epigen & Canc Risk Factors, D-69120 Heidelberg, Germany; 9.Ontario Inst Canc Res, Genome Technol Program, Toronto, ON M5G 0A3, Canada; 10.Univ Hlth Network, Dept Pathol & Lab Med, Toronto Gen Hosp, Toronto, ON M5G 2C4, Canada; 11.Univ Med Ctr Hamburg Eppendorf, Prostate Canc Ctr, Martini Clin, D-20246 Hamburg, Germany; 12.Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada; 13.Univ Toronto, Dept Radiat Oncol, Toronto, ON M5T 1P5, Canada; 14.Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON M5S 1A8, Canada |
推荐引用方式 GB/T 7714 | Hopkins, Julia F.,Sabelnykova, Veronica Y.,Weischenfeldt, Joachim,et al. Mitochondrial mutations drive prostate cancer aggression[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Hopkins, Julia F..,Sabelnykova, Veronica Y..,Weischenfeldt, Joachim.,Simon, Ronald.,Aguiar, Jennifer A..,...&Boutros, Paul C..(2019).Mitochondrial mutations drive prostate cancer aggression.NATURE COMMUNICATIONS,8. |
MLA | Hopkins, Julia F.,et al."Mitochondrial mutations drive prostate cancer aggression".NATURE COMMUNICATIONS 8(2019). |
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