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DOI | 10.1038/s41467-019-11297-4 |
Paternal grandfather's access to food predicts all-cause and cancer mortality in grandsons | |
Vagero, Denny1; Pinger, Pia R.2,3; Aronsson, Vanda1; van den Berg, Gerard J.4,5 | |
2019-07-26 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Sweden; Germany; England |
英文摘要 | Studies of animals and plants suggest that nutritional conditions in one generation may affect phenotypic characteristics in subsequent generations. A small number of human studies claim to show that pre-pubertal nutritional experience trigger a sex-specific transgenerational response along the male line. A single historical dataset, the Overkalix cohorts in northern Sweden, is often quoted as evidence. To test this hypothesis on an almost 40 times larger dataset we collect harvest data during the pre-pubertal period of grandparents (G0, n = 9,039) to examine its potential association with mortality in children (G1, n = 7,280) and grandchildren (G2, n = 11,561) in the Uppsala Multigeneration Study. We find support for the main Overkalix finding: paternal grandfather's food access in pre-puberty predicts his male, but not female, grandchildren's all-cause mortality. In our study, cancer mortality contributes strongly to this pattern. We are unable to reproduce previous results for diabetes and cardiovascular mortality. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000452776500001 |
WOS关键词 | TRANSGENERATIONAL INHERITANCE ; EPIGENETIC INHERITANCE ; PRENATAL EXPOSURE ; DNA METHYLATION ; SPERM RNAS ; NUTRITION ; DISEASE ; RESPONSES ; NUMBER ; HEALTH |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204464 |
专题 | 资源环境科学 |
作者单位 | 1.Stockholm Univ, Dept Publ Hlth Sci, Ctr Hlth Equity Studies, CHESS, SE-10691 Stockholm, Sweden; 2.Univ Bonn, Dept Econ, Adenauerallee 24-42, D-53113 Bonn, Germany; 3.Inst Behav & Inequal, Briq, Bonn, Germany; 4.Univ Bristol, Dept Econ, Priory Rd Complex, Bristol BS8 ITU, Avon, England; 5.Inst Evaluat Labor Market & Educ Policy, IFAU, Uppsala, Sweden |
推荐引用方式 GB/T 7714 | Vagero, Denny,Pinger, Pia R.,Aronsson, Vanda,et al. Paternal grandfather's access to food predicts all-cause and cancer mortality in grandsons[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Vagero, Denny,Pinger, Pia R.,Aronsson, Vanda,&van den Berg, Gerard J..(2019).Paternal grandfather's access to food predicts all-cause and cancer mortality in grandsons.NATURE COMMUNICATIONS,9. |
MLA | Vagero, Denny,et al."Paternal grandfather's access to food predicts all-cause and cancer mortality in grandsons".NATURE COMMUNICATIONS 9(2019). |
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