Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-019-10876-9 |
Distinct roles of XPF-ERCC1 and Rad1-Rad10-Saw1 in replication-coupled and uncoupled inter-strand crosslink repair | |
Seol, Ja-Hwan1; Holland, Cory1; Li, Xiaolei2; Kim, Christopher1; Li, Fuyang1,2; Medina-Rivera, Melisa3; Eichmiller, Robin3; Gallardo, Ignacio F.4; Finkelstein, Ilya J.4; Hasty, Paul1; Shim, Eun Yong2; Surtees, Jennifer A.3; Lee, Sang Eun1,2 | |
2019-07-23 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Yeast Rad1-Rad10 (XPF-ERCC1 in mammals) incises UV, oxidation, and cross -linking agent induced DNA lesions, and contributes to multiple DNA repair pathways. To determine how Rad1-Rad10 catalyzes inter-strand crosslink repair (ICLR), we examined sensitivity to ICLs from yeast deleted for SAW1 and SLX4, which encode proteins that interact physically with Rad1-Rad10 and bind stalled replication forks. Saw1, Slx1, and Slx4 are critical for replication coupled ICLR in mus81 deficient cells. Two rad1 mutations that disrupt interactions between Rpa1 and Rad1-Rad10 selectively disable non-nucleotide excision repair (NER) function, but retain UV lesion repair. Mutations in the analogous region of XPF also compromised XPF interactions with Rpa1 and Slx4, and are proficient in NER but deficient in ICLR and direct repeat recombination. We propose that Rad1-Rad10 makes distinct contributions to ICLR depending on cell cycle phase: in G1, Rad1-Rad10 removes ICL via NER, whereas in S/G2, Rad1-Rad10 facilitates NER-independent replication-coupled ICLR. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000432792100001 |
WOS关键词 | NUCLEOTIDE EXCISION-REPAIR ; STRUCTURE-SPECIFIC ENDONUCLEASES ; HOLLIDAY JUNCTION RESOLVASE ; FANCONI-ANEMIA PATHWAY ; DNA-REPAIR ; SACCHAROMYCES-CEREVISIAE ; HOMOLOGOUS RECOMBINATION ; ERCC1-XPF ENDONUCLEASE ; XERODERMA-PIGMENTOSUM ; MAMMALIAN-CELLS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204463 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Texas Hlth Sci Ctr San Antonio, Inst Biotechnol, Dept Mol Med, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA; 2.Univ Texas Hlth Sci Ctr San Antonio, Dept Radiat Oncol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA; 3.SUNY Buffalo, Jacobs Sch Med & Biomed Sci, Dept Biochem, 955 Main St, Buffalo, NY 14203 USA; 4.Univ Texas Austin, Inst Cellular & Mol Biol, Dept Mol Biosci, Austin, TX 78712 USA |
推荐引用方式 GB/T 7714 | Seol, Ja-Hwan,Holland, Cory,Li, Xiaolei,et al. Distinct roles of XPF-ERCC1 and Rad1-Rad10-Saw1 in replication-coupled and uncoupled inter-strand crosslink repair[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Seol, Ja-Hwan.,Holland, Cory.,Li, Xiaolei.,Kim, Christopher.,Li, Fuyang.,...&Lee, Sang Eun.(2019).Distinct roles of XPF-ERCC1 and Rad1-Rad10-Saw1 in replication-coupled and uncoupled inter-strand crosslink repair.NATURE COMMUNICATIONS,9. |
MLA | Seol, Ja-Hwan,et al."Distinct roles of XPF-ERCC1 and Rad1-Rad10-Saw1 in replication-coupled and uncoupled inter-strand crosslink repair".NATURE COMMUNICATIONS 9(2019). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论