Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-019-10969-5 |
Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability | |
Morgan, Michael D.1,5; Pairo-Castineira, Erola2; Rawlik, Konrad3; Canela-Xandri, Oriol2,3; Rees, Jonathan4; Sims, David1; Tenesa, Albert2,3; Jackson, Ian J.2,3 | |
2019-07-12 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | England; Scotland |
英文摘要 | Natural hair colour within European populations is a complex genetic trait. Previous work has established that MC1R variants are the principal genetic cause of red hair colour, but with variable penetrance. Here, we have extensively mapped the genes responsible for hair colour in the white, British ancestry, participants in UK Biobank. MC1R only explains 73% of the SNP heritability for red hair in UK Biobank, and in fact most individuals with two MC1R variants have blonde or light brown hair. We identify other genes contributing to red hair, the combined effect of which accounts for -90% of the SNP heritability. Blonde hair is associated with over 200 genetic variants and we find a continuum from black through dark and light brown to blonde and account for 73% of the SNP heritability of blonde hair. Many of the associated genes are involved in hair growth or texture, emphasising the cellular connections between keratinocytes and melanocytes in the determination of hair colour. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000452633700011 |
WOS关键词 | GENETIC-DETERMINANTS ; HUMAN PIGMENTATION ; SKIN-CANCER ; RED HAIR ; ASSOCIATION ; HERC2 ; VARIANTS ; RISK ; MC1R ; OCA2 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204449 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Oxford, John Radcliffe Hosp, MRC Weatherall Inst Mol Med, MRC WIMM Ctr Computat Biol, Oxford OX3 9DS, England; 2.Univ Edinburgh, Inst Genet & Mol Med, MRC Human Genet Unit, Crewe Rd, Edinburgh EH4 2XU, Midlothian, Scotland; 3.Univ Edinburgh, Roslin Inst, Easter Bush EH25 9RG, Midlothian, Scotland; 4.Univ Edinburgh, Dermatol, Lauriston Bldg, Edinburgh EH3 9HA, Midlothian, Scotland; 5.Wellcome Trust Sanger Inst, Wellcome Genome Campus, Cambridge CB10 1SA, England |
推荐引用方式 GB/T 7714 | Morgan, Michael D.,Pairo-Castineira, Erola,Rawlik, Konrad,et al. Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Morgan, Michael D..,Pairo-Castineira, Erola.,Rawlik, Konrad.,Canela-Xandri, Oriol.,Rees, Jonathan.,...&Jackson, Ian J..(2019).Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability.NATURE COMMUNICATIONS,9. |
MLA | Morgan, Michael D.,et al."Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability".NATURE COMMUNICATIONS 9(2019). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论