Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-019-10763-3 |
Inverse poroelasticity as a fundamental mechanism in biomechanics and mechanobiology | |
Ehret, Alexander E.1,2; Bircher, Kevin1; Stracuzzi, Alberto1; Marina, Vita1; Zundel, Manuel1; Mazza, Edoardo1,2 | |
2019-07-04 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland |
英文摘要 | Understanding the mechanisms of deformation of biological materials is important for improved diagnosis and therapy, fundamental investigations in mechanobiology, and applications in tissue engineering. Here we demonstrate the essential role of interstitial fluid mobility in determining the mechanical properties of soft tissues. Opposite to the behavior expected for a poroelastic material, the tissue volume of different collagenous membranes is observed to strongly decrease with tensile loading. Inverse poroelasticity governs monotonic and cyclic responses of soft biomembranes, and induces chemo-mechanical coupling, such that tensile forces are modulated by the chemical potential of the interstitial fluid. Correspondingly, the osmotic pressure varies with mechanical loads, thus providing an effective mechanism for mechanotransduction. Water mobility determines the tissue's ability to adapt to deformation through compaction and dilation of the collagen fiber network. In the near field of defects this mechanism activates the reversible formation of reinforcing collagen structures which effectively avoid propagation of cracks. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413118900005 |
WOS关键词 | DEFORMATION-BEHAVIOR ; NONFIBRILLAR MATRIX ; ARTICULAR-CARTILAGE ; MODEL ; STRESS ; GEL ; RESISTANCE ; PRESSURE ; FRACTURE ; NETWORK |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204440 |
专题 | 资源环境科学 |
作者单位 | 1.Swiss Fed Inst Technol, Inst Mech Syst, Leonhardstr 21, CH-8092 Zurich, Switzerland; 2.Empa, Swiss Fed Labs Mat Sci & Technol, Uberlandstr 129, CH-8600 Dubendorf, Switzerland |
推荐引用方式 GB/T 7714 | Ehret, Alexander E.,Bircher, Kevin,Stracuzzi, Alberto,et al. Inverse poroelasticity as a fundamental mechanism in biomechanics and mechanobiology[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Ehret, Alexander E.,Bircher, Kevin,Stracuzzi, Alberto,Marina, Vita,Zundel, Manuel,&Mazza, Edoardo.(2019).Inverse poroelasticity as a fundamental mechanism in biomechanics and mechanobiology.NATURE COMMUNICATIONS,8. |
MLA | Ehret, Alexander E.,et al."Inverse poroelasticity as a fundamental mechanism in biomechanics and mechanobiology".NATURE COMMUNICATIONS 8(2019). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论