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DOI | 10.1038/s41467-019-10821-w |
Systematic generation of biophysically detailed models for diverse cortical neuron types | |
Gouwens, Nathan W.; Berg, Jim; Feng, David; Sorensen, Staci A.; Zeng, Hongkui; Hawrylycz, Michael J.; Koch, Christof; Arkhipov, Anton | |
2019-06-26 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The cellular components of mammalian neocortical circuits are diverse, and capturing this diversity in computational models is challenging. Here we report an approach for generating biophysically detailed models of 170 individual neurons in the Allen Cell Types Database to link the systematic experimental characterization of cell types to the construction of cortical models. We build models from 3D morphologies and somatic electrophysiological responses measured in the same cells. Densities of active somatic conductances and additional parameters are optimized with a genetic algorithm to match electrophysiological features. We evaluate the models by applying additional stimuli and comparing model responses to experimental data. Applying this technique across a diverse set of neurons from adult mouse primary visual cortex, we verify that models preserve the distinctiveness of intrinsic properties between subsets of cells observed in experiments. The optimized models are accessible online alongside the experimental data. Code for optimization and simulation is also openly distributed. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000425382800002 |
WOS关键词 | PYRAMIDAL NEURONS ; SODIUM CURRENT ; WHOLE-CELL ; CHANNELS ; REPOLARIZATION ; INTERNEURONS ; INACTIVATION ; OPTIMIZATION ; CONDUCTANCE ; PARAMETERS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204430 |
专题 | 资源环境科学 |
作者单位 | Allen Inst Brain Sci, 615 Westlake Ave N, Seattle, WA 98109 USA |
推荐引用方式 GB/T 7714 | Gouwens, Nathan W.,Berg, Jim,Feng, David,et al. Systematic generation of biophysically detailed models for diverse cortical neuron types[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Gouwens, Nathan W..,Berg, Jim.,Feng, David.,Sorensen, Staci A..,Zeng, Hongkui.,...&Arkhipov, Anton.(2019).Systematic generation of biophysically detailed models for diverse cortical neuron types.NATURE COMMUNICATIONS,9. |
MLA | Gouwens, Nathan W.,et al."Systematic generation of biophysically detailed models for diverse cortical neuron types".NATURE COMMUNICATIONS 9(2019). |
条目包含的文件 | 条目无相关文件。 |
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