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DOI | 10.1038/s41467-019-10284-z |
Extracellular-matrix-mediated osmotic pressure drives Vibrio cholerae biofilm expansion and cheater exclusion | |
Yan, Jing1,2; Nadell, Carey D.1,3; Stone, Howard A.2; Wingreen, Ned S.1; Bassler, Bonnie L.1,4 | |
2019-05-23 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Germany |
英文摘要 | Biofilms, surface-attached communities of bacteria encased in an extracellular matrix, are a major mode of bacterial life. How the material properties of the matrix contribute to biofilm growth and robustness is largely unexplored, in particular in response to environmental perturbations such as changes in osmotic pressure. Here, using Vibrio cholerae as our model organism, we show that during active cell growth, matrix production enables biofilm-dwelling bacterial cells to establish an osmotic pressure difference between the biofilm and the external environment. This pressure difference promotes biofilm expansion on nutritious surfaces by physically swelling the colony, which enhances nutrient uptake, and enables matrix-producing cells to outcompete non-matrix-producing cheaters via physical exclusion. Osmotic pressure together with crosslinking of the matrix also controls the growth of submerged biofilms and their susceptibility to invasion by planktonic cells. As the basic physicochemical principles of matrix crosslinking and osmotic swelling are universal, our findings may have implications for other biofilm-forming bacterial species. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000408142100004 |
WOS关键词 | TRANSCRIPTIONAL REGULATOR ; BACTERIAL BIOFILMS ; GROWTH ; DETERMINANTS ; ARCHITECTURE ; COOPERATION ; MORPHOLOGY ; TRANSPORT ; RESPONSES ; PATTERN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204382 |
专题 | 资源环境科学 |
作者单位 | 1.Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA; 2.Princeton Univ, Dept Mech & Aerosp Engn, Princeton, NJ 08544 USA; 3.Max Planck Inst Terr Microbiol, D-35043 Marburg, Germany; 4.Howard Hughes Med Inst, Chevy Chase, MD 20815 USA |
推荐引用方式 GB/T 7714 | Yan, Jing,Nadell, Carey D.,Stone, Howard A.,et al. Extracellular-matrix-mediated osmotic pressure drives Vibrio cholerae biofilm expansion and cheater exclusion[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Yan, Jing,Nadell, Carey D.,Stone, Howard A.,Wingreen, Ned S.,&Bassler, Bonnie L..(2019).Extracellular-matrix-mediated osmotic pressure drives Vibrio cholerae biofilm expansion and cheater exclusion.NATURE COMMUNICATIONS,8. |
MLA | Yan, Jing,et al."Extracellular-matrix-mediated osmotic pressure drives Vibrio cholerae biofilm expansion and cheater exclusion".NATURE COMMUNICATIONS 8(2019). |
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