Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma

doi:10.1038/s41467-019-10204-1

GSTDTAP > 资源环境科学

DOI	10.1038/s41467-019-10204-1
	Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma
	Gallia, Gary L.1,2,3; Zhang, Ming 4,5; Ning, Yi 6; Haffner, Michael C.6; Batista, Denise 6; Binder, Zev A.1,10; Bishop, Justin A.6,11; Hann, Christine L.3; Hruban, Ralph H.6; Ishii, Masaru 1,2; Klein, Alison P.3,6; Reh, Douglas D.1,2; Rooper, Lisa M.6; Salmasi, Vafi 1,12; Tamargo, Rafael J.1,2; Wang, Qing 4,5; Williamson, Tara 1; Zhao, Tianna 1; Zou, Ying 7; Meeker, Alan K.6; Agrawal, Nishant 2,13; Vogelstein, Bert 4,5,8; Kinzler, Kenneth W.4,5; Papadopoulos, Nickolas 4,5; Bettegowda, Chetan 1,3,4,5,9
	2019-05-23
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
出版年	2018
卷号	9
文章类型	Article
语种	英语
国家	USA
英文摘要	Olfactory neuroblastoma (ONB) is a rare malignant neoplasm arising in the upper portion of the sinonasal cavity. To better understand the genetic bases for ONB, here we perform whole exome and whole genome sequencing as well as single nucleotide polymorphism array analyses in a series of ONB patient samples. Deletions involving the dystrophin (DMD) locus are found in 12 of 14 (86%) tumors. Interestingly, one of the remaining tumors has a deletion in LAMA2, bringing the number of ONBs with deletions of genes involved in the development of muscular dystrophies to 13 or 93%. This high prevalence implicates an unexpected functional role for genes causing hereditary muscular dystrophies in ONB.
领域	资源环境
收录类别	SCI-E
WOS记录号	WOS:000454136400001
WOS关键词	ESTHESIONEUROBLASTOMA ; MUTATIONS ; CANCER ; GENE ; HYBRIDIZATION ; SURVIVAL ; PATTERNS ; LAMA2 ; MICE ; CGH
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/204380
专题	资源环境科学
作者单位	1.Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD 21287 USA; 2.Johns Hopkins Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21287 USA; 3.Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21287 USA; 4.Johns Hopkins Univ, Sch Med, Dept Pathol & Oncol, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21287 USA; 5.Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21287 USA; 6.Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21287 USA; 7.Univ Maryland, Sch Med, Dept Pathol, Baltimore, MD 21201 USA; 8.Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21287 USA; 9.Johns Hopkins Univ, Sch Med, Dept Radiat Oncol, Baltimore, MD 21287 USA; 10.Univ Penn, Dept Neurosurg, Philadelphia, PA 19104 USA; 11.Univ Texas Southwestern Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA; 12.Stanford Univ, Sch Med, Dept Anesthesiol Perioperat & Pain Med, Palo Alto, CA 94305 USA; 13.Univ Chicago, Dept Surg, Div Otolaryngol & Head & Neck Surg, 5841 S Maryland Ave, Chicago, IL 60637 USA
推荐引用方式 GB/T 7714	Gallia, Gary L.,Zhang, Ming,Ning, Yi,et al. Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma[J]. NATURE COMMUNICATIONS,2019,9.
APA	Gallia, Gary L..,Zhang, Ming.,Ning, Yi.,Haffner, Michael C..,Batista, Denise.,...&Bettegowda, Chetan.(2019).Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma.NATURE COMMUNICATIONS,9.
MLA	Gallia, Gary L.,et al."Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma".NATURE COMMUNICATIONS 9(2019).