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DOI | 10.1038/s41467-019-10063-w |
Gold nanocrystal-mediated sliding of doublet DNA origami filaments | |
Urban, Maximilian J.1,2; Both, Steffen3,4; Zhou, Chao1,2; Kuzyk, Anton1,5; Lindfors, Klas6; Weiss, Thomas3,4; Liu, Na1,2 | |
2019-05-15 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; Finland |
英文摘要 | Sliding is one of the fundamental mechanical movements in machinery. In macroscopic systems, double-rack pinion machines employ gears to slide two linear tracks along opposite directions. In microscopic systems, kinesin-5 proteins crosslink and slide apart antiparallel microtubules, promoting spindle bipolarity and elongation during mitosis. Here we demonstrate an artificial nanoscopic analog, in which gold nanocrystals can mediate coordinated sliding of two antiparallel DNA origami filaments powered by DNA fuels. Stepwise and reversible sliding along opposite directions is in situ monitored and confirmed using fluorescence spectroscopy. A theoretical model including different energy transfer mechanisms is developed to understand the observed fluorescence dynamics. We further show that such sliding can also take place in the presence of multiple DNA sidelocks that are introduced to inhibit the relative movements. Our work enriches the toolbox of DNA-based nanomachinery, taking one step further toward the vision of molecular nanofactories. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000429921000011 |
WOS关键词 | SELF-ORGANIZATION ; MOLECULAR MOTOR ; WALKER ; MICROTUBULES ; PROTEINS ; KINETICS ; DEVICES ; WALKING ; MOTION ; MOVES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204365 |
专题 | 资源环境科学 |
作者单位 | 1.Max Planck Inst Intelligent Syst, Heisenbergstr 3, D-70569 Stuttgart, Germany; 2.Heidelberg Univ, Kirchhoff Inst Phys, Neuenheimer Feld 227, D-69120 Heidelberg, Germany; 3.Univ Stuttgart, Phys Inst 4, D-70569 Stuttgart, Germany; 4.Univ Stuttgart, Stuttgart Res Ctr Photon Engn, D-70569 Stuttgart, Germany; 5.Aalto Univ, Sch Sci, Dept Neurosci & Biomed Engn, POB 12200, FI-00076 Aalto, Finland; 6.Univ Cologne, Dept Chem, Luxemburger Str 116, D-50939 Cologne, Germany |
推荐引用方式 GB/T 7714 | Urban, Maximilian J.,Both, Steffen,Zhou, Chao,et al. Gold nanocrystal-mediated sliding of doublet DNA origami filaments[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Urban, Maximilian J..,Both, Steffen.,Zhou, Chao.,Kuzyk, Anton.,Lindfors, Klas.,...&Liu, Na.(2019).Gold nanocrystal-mediated sliding of doublet DNA origami filaments.NATURE COMMUNICATIONS,9. |
MLA | Urban, Maximilian J.,et al."Gold nanocrystal-mediated sliding of doublet DNA origami filaments".NATURE COMMUNICATIONS 9(2019). |
条目包含的文件 | 条目无相关文件。 |
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