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DOI | 10.1038/s41467-019-09714-9 |
Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation | |
Pircher, Joachim1,2; Czermak, Thomas1; Ehrlich, Andreas1; Eberle, Clemens1; Gaitzsch, Erik3; Margraf, Andreas3; Grommes, Jochen4,5; Saha, Prakash6; Titova, Anna1; Ishikawa-Ankerhold, Hellen1; Stark, Konstantin1,2; Petzold, Tobias1,2; Stocker, Thomas1; Weckbach, Ludwig T.1,3; Novotny, Julia1; Sperandio, Markus2,3; Nieswandt, Bernhard7,8; Smith, Alberto6; Mannell, Hanna3; Walzog, Barbara3; Horst, David9; Soehnlein, Oliver2,4,10; Massberg, Steffen1,2; Schulz, Christian1,2 | |
2019-04-23 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; England; Sweden |
英文摘要 | Leukocyte-released antimicrobial peptides contribute to pathogen elimination and activation of the immune system. Their role in thrombosis is incompletely understood. Here we show that the cathelicidin LL-37 is abundant in thrombi from patients with acute myocardial infarction. Its mouse homologue, CRAMP, is present in mouse arterial thrombi following vascular injury, and derives mainly from circulating neutrophils. Absence of hematopoietic CRAMP in bone marrow chimeric mice reduces platelet recruitment and thrombus formation. Both LL-37 and CRAMP induce platelet activation in vitro by involving glycoprotein VI receptor with downstream signaling through protein tyrosine kinases Src/Syk and phospholipase C. In addition to acute thrombosis, LL-37/CRAMP-dependent platelet activation fosters platelet-neutrophil interactions in other inflammatory conditions by modulating the recruitment and extravasation of neutrophils into tissues. Absence of CRAMP abrogates acid-induced lung injury, a mouse pneumonia model that is dependent on platelet-neutrophil interactions. We suggest that LL-37/CRAMP represents an important mediator of platelet activation and thrombo-inflammation. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000430286500004 |
WOS关键词 | ANTIMICROBIAL PEPTIDE LL-37 ; LEUKOCYTE RECRUITMENT ; MONOCLONAL-ANTIBODY ; EXTRACELLULAR DNA ; NEUTROPHILS ; SYK ; ACTIVATION ; ADHESION ; INJURY ; IDENTIFICATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204331 |
专题 | 资源环境科学 |
作者单位 | 1.Ludwig Maximilians Univ Munchen, Klinikum Univ Munchen, Med Klin & Poliklin 1, D-81377 Munich, Germany; 2.Partner Site Munich Heart Alliance, DZHK German Ctr Cardiovasc Res, D-80802 Munich, Germany; 3.Ludwig Maximilians Univ Munchen, Walter Brendel Ctr Expt Med, Dept Cardiovasc Physiol & Pathophysiol, Biomed Ctr, D-82152 Munich, Germany; 4.Ludwig Maximilians Univ Munchen, Inst Cardiovasc Prevent IPEK, D-80336 Munich, Germany; 5.Uniklin RWTH, Klin Gefasschirurg, D-52074 Aachen, Germany; 6.Kings Coll London, St Thomas Hosp, Acad Dept Vasc Surg, London SE1 7EH, England; 7.Univ Hosp Wurzburg, Dept Expt Biomed, D-97080 Wurzburg, Germany; 8.Univ Wurzburg, Rudolf Virchow Ctr, D-97080 Wurzburg, Germany; 9.Ludwig Maximilians Univ Munchen, Pathol Inst, D-80337 Munich, Germany; 10.Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden |
推荐引用方式 GB/T 7714 | Pircher, Joachim,Czermak, Thomas,Ehrlich, Andreas,et al. Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Pircher, Joachim.,Czermak, Thomas.,Ehrlich, Andreas.,Eberle, Clemens.,Gaitzsch, Erik.,...&Schulz, Christian.(2019).Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation.NATURE COMMUNICATIONS,9. |
MLA | Pircher, Joachim,et al."Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation".NATURE COMMUNICATIONS 9(2019). |
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