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DOI | 10.1038/s41467-019-09506-1 |
Honey bee Royalactin unlocks conserved pluripotency pathway in mammals | |
Wan, Derrick C.1,2; Morgan, Stefanie L.1,3; Spencley, Andrew L.1; Mariano, Natasha1; Chang, Erin Y.1; Shankar, Gautam1; Luo, Yunhai1; Li, Ted H.1; Huh, Dana1; Huynh, Star K.1; Garcia, Jasmine M.1; Dovey, Cole M.4; Lumb, Jennifer4; Liu, Ling5,6; Brown, Katharine V.7; Bermudez, Abel8; Luong, Richard9; Zeng, Hong10; Mascetti, Victoria L.10; Pitteri, Sharon J.8; Wang, Jordon11; Tu, Hua11; Quarta, Marco5,6; Sebastiano, Vittorio10; Nusse, Roel7; Rando, Thomas A.5,6; Carette, Jan E.4; Bazan, J. Fernando12; Wang, Kevin C.1,3,13 | |
2019-04-16 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Royal jelly is the queen-maker for the honey bee Apis mellifera, and has cross-species effects on longevity, fertility, and regeneration in mammals. Despite this knowledge, how royal jelly or its components exert their myriad effects has remained poorly understood. Using mouse embryonic stem cells as a platform, here we report that through its major protein component Royalactin, royal jelly can maintain pluripotency by activating a ground-state pluripotency-like gene network. We further identify Regina, a mammalian structural analog of Royalactin that also induces a naive-like state in mouse embryonic stem cells. This reveals an important innate program for stem cell self-renewal with broad implications in understanding the molecular regulation of stem cell fate across species. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000452040500001 |
WOS关键词 | GROUND-STATE ; CELL-LINE ; PROTEIN ; DIFFERENTIATION ; DERIVATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204326 |
专题 | 资源环境科学 |
作者单位 | 1.Stanford Univ, Sch Med, Dept Dermatol, Program Epithelial Biol, Stanford, CA 94305 USA; 2.Stanford Univ, Sch Med, Hagey Lab Pediat Regenerat Med, Stanford, CA 94305 USA; 3.Stanford Univ, Sch Med, Program Canc Biol, Stanford, CA 94305 USA; 4.Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA; 5.Stanford Univ, Sch Med, Glenn Labs Biol Aging, Stanford, CA 94305 USA; 6.Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA; 7.Stanford Univ, Sch Med, Stanford Inst Stem Cell Biol & Regenerat Med, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USA; 8.Stanford Univ, Sch Med, Dept Radiol, Canary Ctr Canc Early Detect, Palo Alto, CA 94304 USA; 9.Stanford Univ, Sch Med, Dept Comparat Med, Stanford, CA 94305 USA; 10.Stanford Univ, Sch Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA; 11.LakePharma Inc, Belmont, CA 94002 USA; 12.R&D Syst Inc, Minneapolis, MN 55413 USA; 13.Vet Affairs Palo Alto Healthcare Syst, Palo Alto, CA 94304 USA |
推荐引用方式 GB/T 7714 | Wan, Derrick C.,Morgan, Stefanie L.,Spencley, Andrew L.,et al. Honey bee Royalactin unlocks conserved pluripotency pathway in mammals[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Wan, Derrick C..,Morgan, Stefanie L..,Spencley, Andrew L..,Mariano, Natasha.,Chang, Erin Y..,...&Wang, Kevin C..(2019).Honey bee Royalactin unlocks conserved pluripotency pathway in mammals.NATURE COMMUNICATIONS,9. |
MLA | Wan, Derrick C.,et al."Honey bee Royalactin unlocks conserved pluripotency pathway in mammals".NATURE COMMUNICATIONS 9(2019). |
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