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DOI | 10.1038/s41467-019-09410-8 |
EGFL7 reduces CNS inflammation in mouse | |
Larochelle, Catherine1,2,3; Uphaus, Timo1; Broux, Bieke2,3; Gowing, Elizabeth2,3; Paterka, Magdalena1; Michel, Laure2,3; Stankovic, Nevenka Dudvarski4,5,6; Bicker, Frank4; Lemaitre, Florent2,3; Prat, Alexandre2,3; Schmidt, Mirko H. H.4; Zipp, Frauke1 | |
2019-04-12 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; Canada |
英文摘要 | Extracellular matrix (ECM) proteins secreted by blood-brain barrier (BBB) endothelial cells (ECs) are implicated in cell trafficking. We discovered that the expression of ECM epidermal growth factor-like protein 7 (EGFL7) is increased in the CNS vasculature of patients with multiple sclerosis (MS), and in mice with experimental autoimmune encephalomyelitis (EAE). Perivascular CD4 T lymphocytes colocalize with ECM-bound EGFL7 in MS lesions. Human and mouse activated T cells upregulate EGFL7 ligand alpha v beta 3 integrin and can adhere to EGFL7 through integrin alpha v beta 3. EGFL7-knockout (KO) mice show earlier onset of EAE and increased brain and spinal cord parenchymal infiltration of T lymphocytes. Importantly, EC-restricted EGFL7-KO is associated with a similar EAE worsening. Finally, treatment with recombinant EGFL7 improves EAE, reduces MCAM expression, and tightens the BBB in mouse. Our data demonstrate that EGFL7 can limit CNS immune infiltration and may represent a novel therapeutic avenue in MS. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000426048900006 |
WOS关键词 | BLOOD-BRAIN-BARRIER ; CENTRAL-NERVOUS-SYSTEM ; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; ENDOTHELIAL-CELL ACTIVATION ; DOMAIN 7 EGFL7 ; MULTIPLE-SCLEROSIS ; T-LYMPHOCYTES ; ALPHA(V)BETA(3) INTEGRIN ; MICRORNA MIR-126 ; EXPRESSION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204319 |
专题 | 资源环境科学 |
作者单位 | 1.Johannes Gutenberg Univ Mainz, Univ Med Ctr, Rhine Main Neurosci Network Rmn2, Dept Neurol,Focus Program Translat Neurosci FTN,R, Langenbeckstr 1, D-55131 Mainz, Germany; 2.CRCHUM, Neuroimmunol Unit, Montreal, PQ, Canada; 3.Univ Montreal, Fac Med, Dept Neurosci, 900 Rue St Denis, Montreal, PQ H2X OA9, Canada; 4.Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Microscop Anat & Neurobiol,Rhine Main Neuros, Mol Signal Transduct Labs,Focus Program Translat, Langenbeckstr 1, D-55131 Mainz, Germany; 5.German Canc Consortium DKTK, Neuenheimer Feld 280, D-69120 Heidelberg, Germany; 6.German Canc Res Ctr, Neuenheimer Feld 280, D-69120 Heidelberg, Germany |
推荐引用方式 GB/T 7714 | Larochelle, Catherine,Uphaus, Timo,Broux, Bieke,et al. EGFL7 reduces CNS inflammation in mouse[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Larochelle, Catherine.,Uphaus, Timo.,Broux, Bieke.,Gowing, Elizabeth.,Paterka, Magdalena.,...&Zipp, Frauke.(2019).EGFL7 reduces CNS inflammation in mouse.NATURE COMMUNICATIONS,9. |
MLA | Larochelle, Catherine,et al."EGFL7 reduces CNS inflammation in mouse".NATURE COMMUNICATIONS 9(2019). |
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