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DOI | 10.1038/s41467-019-09242-6 |
Chiral DOTA chelators as an improved platform for biomedical imaging and therapy applications | |
Dai, Lixiong1; Jones, Chloe M.2,3; Chan, Wesley Ting Kwok1; Pham, Tiffany A.4; Ling, Xiaoxi5; Gale, Eric M.2,3; Rotile, Nicholas J.2,3; Tai, William Chi-Shing1; Anderson, Carolyn J.4,5,6,7; Caravan, Peter2,3; Law, Ga-Lai1 | |
2019-04-09 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA |
英文摘要 | Despite established clinical utilisation, there is an increasing need for safer, more inert gadolinium-based contrast agents, and for chelators that react rapidly with radiometals. Here we report the syntheses of a series of chiral DOTA chelators and their corresponding metal complexes and reveal properties that transcend the parent DOTA compound. We incorporated symmetrical chiral substituents around the tetraaza ring, imparting enhanced rigidity to the DOTA cavity, enabling control over the range of stereoisomers of the lanthanide complexes. The Gd chiral DOTA complexes are shown to be orders of magnitude more inert to Gd release than [GdDOTA](-). These compounds also exhibit very-fast water exchange rates in an optimal range for high field imaging. Radiolabeling studies with (Cu-64/Lu-177) also demonstrate faster labelling properties. These chiral DOTA chelators are alternative general platforms for the development of stable, high relaxivity contrast agents, and for radiometal complexes used for imaging and/or therapy. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000426152900001 |
WOS关键词 | MRI CONTRAST AGENTS ; NEPHROGENIC SYSTEMIC FIBROSIS ; CIRCULARLY-POLARIZED LUMINESCENCE ; WATER-EXCHANGE-RATES ; GADOLINIUM DEPOSITION ; CONFORMATIONAL MOBILITY ; ALKYL SUBSTITUTION ; SERUM-ALBUMIN ; HEALTHY RATS ; O-17 NMR |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204314 |
专题 | 资源环境科学 |
作者单位 | 1.Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China; 2.Massachusetts Gen Hosp, Dept Radiol, Inst Innovat Imaging, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA; 3.Harvard Med Sch, Charlestown, MA 02129 USA; 4.Univ Pittsburgh, Dept Radiol, Pittsburgh, PA 15213 USA; 5.Univ Pittsburgh, Dept Med, Pittsburgh, PA 15261 USA; 6.Univ Pittsburgh, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15213 USA; 7.Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA 15213 USA |
推荐引用方式 GB/T 7714 | Dai, Lixiong,Jones, Chloe M.,Chan, Wesley Ting Kwok,et al. Chiral DOTA chelators as an improved platform for biomedical imaging and therapy applications[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Dai, Lixiong.,Jones, Chloe M..,Chan, Wesley Ting Kwok.,Pham, Tiffany A..,Ling, Xiaoxi.,...&Law, Ga-Lai.(2019).Chiral DOTA chelators as an improved platform for biomedical imaging and therapy applications.NATURE COMMUNICATIONS,9. |
MLA | Dai, Lixiong,et al."Chiral DOTA chelators as an improved platform for biomedical imaging and therapy applications".NATURE COMMUNICATIONS 9(2019). |
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