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DOI | 10.1038/s41467-019-09554-7 |
Sequence-selective encapsulation and protection of long peptides by a self-assembled (Fe8L6)-L-II cubic cage | |
Mosquera, Jesus; Szyszko, Bartosz; Ho, Sarah K. Y.; Nitschke, Jonathan R. | |
2019-04-03 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | England |
英文摘要 | Self-assembly offers a general strategy for the preparation of large, hollow high-symmetry structures. Although biological capsules, such as virus capsids, are capable of selectively recognizing complex cargoes, synthetic encapsulants have lacked the capability to specifically bind large and complex biomolecules. Here we describe a cubic host obtained from the self-assembly of FeII and a zinc-porphyrin-containing ligand. This cubic cage is flexible and compatible with aqueous media. Its selectivity of encapsulation is driven by the coordination of guest functional groups to the zinc porphyrins. This new host thus specifically encapsulates guests incorporating imidazole and thiazole moieties, including drugs and peptides. Once encapsulated, the reactivity of a peptide is dramatically altered: encapsulated peptides are protected from trypsin hydrolysis, whereas physicochemically similar peptides that do not bind are cleaved. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000397798500001 |
WOS关键词 | PROTEIN ENCAPSULATION ; BINDING ; CATALYSIS ; CAVITY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204299 |
专题 | 资源环境科学 |
作者单位 | Univ Cambridge, Dept Chem, Lensfield Rd, Cambridge CB2 1EW, England |
推荐引用方式 GB/T 7714 | Mosquera, Jesus,Szyszko, Bartosz,Ho, Sarah K. Y.,et al. Sequence-selective encapsulation and protection of long peptides by a self-assembled (Fe8L6)-L-II cubic cage[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Mosquera, Jesus,Szyszko, Bartosz,Ho, Sarah K. Y.,&Nitschke, Jonathan R..(2019).Sequence-selective encapsulation and protection of long peptides by a self-assembled (Fe8L6)-L-II cubic cage.NATURE COMMUNICATIONS,8. |
MLA | Mosquera, Jesus,et al."Sequence-selective encapsulation and protection of long peptides by a self-assembled (Fe8L6)-L-II cubic cage".NATURE COMMUNICATIONS 8(2019). |
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