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DOI | 10.1038/s41467-019-09306-7 |
Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts | |
Torralba, Daniel1,2; Baixauli, Francesc1,3; Villarroya-Beltri, Carolina1,2; Fernandez-Delgado, Irene1,2; Latorre-Pellicer, Ana4; Acin-Perez, Rebeca5; Martin-Cofreces, Noa B.1,2,6; Jaso-Tamame, Angel Luis7; Iborra, Salvador5; Jorge, Inmaculada6,8; Gonzalez-Aseguinolaza, Gloria9; Garaude, Johan5; Vicente-Manzanares, Miguel10; Antonio Enriquez, Jose5,11; Mittelbrunn, Maria12,13; Sanchez-Madrid, Francisco1,2,6 | |
2019-03-21 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Spain; Germany; England |
英文摘要 | Interaction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but whether this interaction has physiological consequences on DC function is largely unexplored. Here we show that when antigen-bearing DCs contact T cells, DCs initiate antipathogenic programs. Signals of this interaction are transmitted from the T cell to the DC, through extracellular vesicles (EV) that contain genomic and mitochondrial DNA, to induce antiviral responses via the cGAS/STING cytosolic DNA-sensing pathway and expression of IRF3-dependent interferon regulated genes. Moreover, EV-treated DCs are more resistant to subsequent viral infections. In summary, our results show that T cells prime DCs through the transfer of exosomal DNA, supporting a specific role for antigen-dependent contacts in conferring protection to DCs against pathogen infection. The reciprocal communication between innate and adaptive immune cells thus allow efficacious responses to unknown threats. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000437834400005 |
WOS关键词 | MITOCHONDRIAL-DNA ; IMMUNOLOGICAL SYNAPSE ; IMMUNE-RESPONSES ; CANCER-CELLS ; IN-VIVO ; KAPPA-B ; EXOSOMES ; RELEASE ; INNATE ; IDENTIFICATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204276 |
专题 | 资源环境科学 |
作者单位 | 1.CNIC, Vasc Pathophysiol Res Area, Madrid 28029, Spain; 2.Univ Autonoma Madrid, Inst Invest Sanitaria Princesa, Serv Inmunol, Diego de Leon 62, Madrid 28006, Spain; 3.Max Planck Inst Immunobiol & Epigenet, Immunometab Dept, D-79108 Freiburg, Germany; 4.Univ Santiago de Compostela, CIBERER, Grp Med Xenom, Santiago De Compostela 15782, Spain; 5.CNIC, Myocardial Pathophysiol Res Area, Madrid 28029, Spain; 6.Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Melchor Fernandez Almagro 3, Madrid 28029, Spain; 7.Imperial Coll Fac Med, MRC Clin Sci Ctr, London SW7 2AZ, England; 8.CNIC, Lab Cardiovasc Prote, Madrid 28029, Spain; 9.Univ Navarra, CIMA, Pamplona 31008, Spain; 10.Inst Biol Mol & Celular Canc USAL CSIC, Salamanca 37007, Spain; 11.Ctr Invest RED CIBERFES, Melchor Fernandez Almagro 9, Madrid 28029, Spain; 12.Hosp 12 Octubre I 12, Inst Invest Sanitaria, Madrid 28041, Spain; 13.UAM CSIC, Dept Biol Celular & Inflamac, Ctr Biol Mol, Madrid 28049, Spain |
推荐引用方式 GB/T 7714 | Torralba, Daniel,Baixauli, Francesc,Villarroya-Beltri, Carolina,et al. Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Torralba, Daniel.,Baixauli, Francesc.,Villarroya-Beltri, Carolina.,Fernandez-Delgado, Irene.,Latorre-Pellicer, Ana.,...&Sanchez-Madrid, Francisco.(2019).Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts.NATURE COMMUNICATIONS,9. |
MLA | Torralba, Daniel,et al."Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts".NATURE COMMUNICATIONS 9(2019). |
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