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DOI | 10.1038/s41467-019-09102-3 |
A retinoraphe projection regulates serotonergic activity and looming-evoked defensive behaviour | |
Huang, Lu1,2; Yuan, Tifei3; Tan, Minjie1,2; Xi, Yue1,2; Hu, Yu1,2; Tao, Qian4; Zhao, Zhikai1,2; Zheng, Jiajun1,2; Han, Yushui1,2; Xu, Fuqiang5; Luo, Minmin6; Sollars, Patricia J.7; Pu, Mingliang8; Pickard, Gary E.7,9; So, Kwok-Fai1,2,10,11,12; Ren, Chaoran1,2,12 | |
2019-03-07 | |
发表期刊 | NATURE COMMUNICATIONS
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ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA |
英文摘要 | Animals promote their survival by avoiding rapidly approaching objects that indicate threats. In mice, looming-evoked defensive responses are triggered by the superior colliculus (SC) which receives direct retinal inputs. However, the specific neural circuits that begin in the retina and mediate this important behaviour remain unclear. Here we identify a subset of retinal ganglion cells (RGCs) that controls mouse looming-evoked defensive responses through axonal collaterals to the dorsal raphe nucleus (DRN) and SC. Looming signals transmitted by DRN-projecting RGCs activate DRN GABAergic neurons that in turn inhibit serotoninergic neurons. Moreover, activation of DRN serotoninergic neurons reduces looming-evoked defensive behaviours. Thus, a dedicated population of RGCs signals rapidly approaching visual threats and their input to the DRN controls a serotonergic self-gating mechanism that regulates innate defensive responses. Our study provides new insights into how the DRN and SC work in concert to extract and translate visual threats into defensive behavioural responses. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000397881600001 |
WOS关键词 | RETINAL GANGLION-CELLS ; IMPENDING COLLISION ; 5-HT1A RECEPTORS ; CONDITIONED FEAR ; INNATE FEAR ; NEURONS ; RESPONSES ; REWARD ; INNERVATION ; COMPUTATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204251 |
专题 | 资源环境科学 |
作者单位 | 1.Jinan Univ, CNS Regenerat Collaborat Joint Lab, Minist Educ, Guangdong Hongkong Macau Inst CNS Regenerat, Guangzhou 510632, Guangdong, Peoples R China; 2.Jinan Univ, Guangdong Key Lab Brain Funct & Dis, Guangzhou 510632, Guangdong, Peoples R China; 3.Nanjing Normal Univ, Sch Psychol, Nanjing 210097, Jiangsu, Peoples R China; 4.Jinan Univ, Sch Med, Dept Psychol, Guangzhou 510632, Guangdong, Peoples R China; 5.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China; 6.Natl Inst Biol Sci, Zhongguancun Life Sci, Pk 7 Sci Pk Rd, Beijing 102206, Peoples R China; 7.Univ Nebraska, Sch Vet Med & Biomed Sci, Lincoln, NE 68583 USA; 8.Peking Univ, Dept Anat, Sch Basic Med Sci, Beijing 100191, Peoples R China; 9.Univ Nebraska, Med Ctr, Dept Ophthalmol & Visual Sci, 600 S 42nd St, Omaha, NE 68198 USA; 10.Univ Hong Kong, Dept Ophthalmol, Hong Kong, Hong Kong, Peoples R China; 11.Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Hong Kong, Peoples R China; 12.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226001, Peoples R China |
推荐引用方式 GB/T 7714 | Huang, Lu,Yuan, Tifei,Tan, Minjie,et al. A retinoraphe projection regulates serotonergic activity and looming-evoked defensive behaviour[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Huang, Lu.,Yuan, Tifei.,Tan, Minjie.,Xi, Yue.,Hu, Yu.,...&Ren, Chaoran.(2019).A retinoraphe projection regulates serotonergic activity and looming-evoked defensive behaviour.NATURE COMMUNICATIONS,8. |
MLA | Huang, Lu,et al."A retinoraphe projection regulates serotonergic activity and looming-evoked defensive behaviour".NATURE COMMUNICATIONS 8(2019). |
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