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| DOI | 10.1038/s41467-019-08564-9 |
| Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus | |
| Liang, Jiankai1; Guo, Li1; Li, Kai2; Xiao, Xiao3; Zhu, Wenbo1; Zheng, Xiaoke4; Hu, Jun5; Zhang, Haipeng1; Cai, Jing1; Yu, Yaya1; Tan, Yaqian1; Li, Chuntao1; Liu, Xincheng1; Hu, Cheng6; Liu, Ying7; Qiu, Pengxin1; Su, Xingwen1; He, Songmin8; Lin, Yuan1,9; Yan, Guangmei1 | |
| 2019-02-14 | |
| 发表期刊 | NATURE COMMUNICATIONS
 |
| ISSN | 2041-1723 |
| 出版年 | 2018 |
| 卷号 | 9 |
| 文章类型 | Article |
| 语种 | 英语 |
| 国家 | Peoples R China; USA |
| 英文摘要 | Oncolytic virus is an attractive anticancer agent that selectively lyses cancer through targeting cancer cells rather than normal cells. Although M1 virus is effective against several cancer types, certain cancer cells present low sensitivity to it. Here we identified that most of the components in the cholesterol biosynthesis pathway are downregulated after M1 virus infection. Further functional studies illustrate that mevalonate/protein farnesylation/ras homolog family member Q (RHOQ) axis inhibits M1 virus replication. Further transcriptome analysis shows that RHOQ knockdown obviously suppresses Rab GTPase and ATP-mediated membrane transporter system, which may mediate the antiviral effect of RHOQ. Based on this, inhibition of the above pathway significantly enhances the anticancer potency of M1 virus in vitro, in vivo, and ex vivo. Our research provides an intriguing strategy for the rational combination of M1 virus with farnesyl transferase inhibitors to enhance therapeutic efficacy. |
| 领域 | 资源环境 |
| 收录类别 | SCI-E |
| WOS记录号 | WOS:000430286500005 |
| WOS关键词 | PROTEIN PRENYLATION ; IMMUNE-RESPONSE ; REPLICATION ; IDENTIFICATION ; ACTIVATION ; ALPHAVIRUS ; TIPIFARNIB ; STEROLS ; ATPASES ; COMPLEX |
| WOS类目 | Multidisciplinary Sciences |
| WOS研究方向 | Science & Technology - Other Topics |
| URL | 查看原文 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204220 |
| 专题 | 资源环境科学 |
| 作者单位 | 1.Sun Yat Sen Univ, Zhongshan Sch Med, Dept Pharmacol, Guangzhou 510080, Guangdong, Peoples R China; 2.Sun Yat Sen Univ, Affiliated Hosp 6, Guangdong Prov Key Lab Colorectal & Pelv Floor Di, Guangzhou 510655, Guangdong, Peoples R China; 3.Sun Yat Sen Univ, Affiliated Hosp 3, Dept Pharm, Guangzhou 510080, Guangdong, Peoples R China; 4.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Pathol, Guangzhou 510080, Guangdong, Peoples R China; 5.Sun Yat Sen Univ, Zhongshan Sch Med, Dept Microbiol, Guangzhou 510080, Guangdong, Peoples R China; 6.Sun Yat Sen Univ, Affiliated Hosp 3, Dept Urol, Guangzhou 510080, Guangdong, Peoples R China; 7.Sun Yat Sen Univ, Affiliated Hosp 3, Dept Infect Dis, Guangzhou 510080, Guangdong, Peoples R China; 8.Weill Cornell Med Coll, Appel Alzheimers Dis Res Inst, Brain & Mind Res Inst, New York, NY 10021 USA; 9.Sun Yat Sen Univ, Sch Publ Hlth, Dept Med Stat & Epidemiol, Guangzhou 510080, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Jiankai,Guo, Li,Li, Kai,et al. Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus[J]. NATURE COMMUNICATIONS,2019,9. |
| APA | Liang, Jiankai.,Guo, Li.,Li, Kai.,Xiao, Xiao.,Zhu, Wenbo.,...&Yan, Guangmei.(2019).Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus.NATURE COMMUNICATIONS,9. |
| MLA | Liang, Jiankai,et al."Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus".NATURE COMMUNICATIONS 9(2019). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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