Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-019-08606-2 |
APC2 controls dendrite development by promoting microtubule dynamics | |
Kahn, lga I.; Schatzle, Philipp; van de Willige, Dieudonnee; Tas, Roderick P.; Lindhout, Feline W.; Portegies, Sybren; Kapitein, Lukas C.; Hoogenraad, Casper C. | |
2019-02-08 | |
发表期刊 | NATURE COMMUNICATIONS
![]() |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Netherlands |
英文摘要 | Mixed polarity microtubule organization is the signature characteristic of vertebrate dendrites. Oppositely oriented microtubules form the basis for selective cargo trafficking in neurons, however the mechanisms that establish and maintain this organization are unclear. Here, we show that APC2, the brain-specific homolog of tumor-suppressor protein adenomatous polyposis coli (APC), promotes dynamics of minus-end-out microtubules in dendrites. We found that APC2 localizes as distinct clusters along microtubule bundles in dendrites and that this localization is driven by LC8-binding and two separate microtubule-interacting domains. Depletion of APC2 reduces the plus end dynamics of minus-end-out oriented microtubules, increases microtubule sliding, and causes defects in dendritic morphology. We propose a model in which APC2 regulates dendrite development by promoting dynamics of minus-end-out microtubules. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000438856900013 |
WOS关键词 | ADENOMATOUS POLYPOSIS-COLI ; CYTOPLASMIC DYNEIN ; SOTOS SYNDROME ; ACTIN ORGANIZATION ; BINDING PROTEIN ; GOLGI OUTPOSTS ; POLARITY ; DROSOPHILA ; NEURONS ; AXONS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204209 |
专题 | 资源环境科学 |
作者单位 | Univ Utrecht, Fac Sci, Dept Biol, Cell Biol, NL-3584 CH Utrecht, Netherlands |
推荐引用方式 GB/T 7714 | Kahn, lga I.,Schatzle, Philipp,van de Willige, Dieudonnee,et al. APC2 controls dendrite development by promoting microtubule dynamics[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Kahn, lga I..,Schatzle, Philipp.,van de Willige, Dieudonnee.,Tas, Roderick P..,Lindhout, Feline W..,...&Hoogenraad, Casper C..(2019).APC2 controls dendrite development by promoting microtubule dynamics.NATURE COMMUNICATIONS,9. |
MLA | Kahn, lga I.,et al."APC2 controls dendrite development by promoting microtubule dynamics".NATURE COMMUNICATIONS 9(2019). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论