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DOI | 10.1038/s41467-018-08238-y |
The role of alternative polyadenylation in the antiviral innate immune response | |
Jia, Xin1; Yuan, Shaochun1; Wang, Yao1; Fu, Yonggui1; Ge, Yong1; Ge, Yutong1; Lan, Xihong1; Feng, Yuchao1; Qiu, Feifei1; Li, Peiyi1; Chen, Shangwu1; Xu, Anlong1,2 | |
2019-01-18 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2017 |
卷号 | 8 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | Alternative polyadenylation (APA) is an important regulatory mechanism of gene functions in many biological processes. However, the extent of 3' UTR variation and the function of APA during the innate antiviral immune response are unclear. Here, we show genome-wide poly(A) sites switch and average 3' UTR length shortens gradually in response to vesicular stomatitis virus (VSV) infection in macrophages. Genes with APA and mRNA abundance change are enriched in immune-related categories such as the Toll-like receptor, RIG-I-like receptor, JAK-STAT and apoptosis-related signalling pathways. The expression of 3' processing factors is down-regulated upon VSV infection. When the core 3' processing factors are knocked down, viral replication is affected. Thus, our study reports the annotation of genes with APA in antiviral immunity and highlights the roles of 3' processing factors on 3' UTR variation upon viral infection. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000394645400001 |
WOS关键词 | 3' ; UNTRANSLATED REGIONS ; TOLL-LIKE RECEPTOR-9 ; DOUBLE-STRANDED-RNA ; RIG-I ; MESSENGER-RNAS ; CELL-DEATH ; INTERFERON ; RECOGNITION ; CLEAVAGE ; UTRS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204177 |
专题 | 资源环境科学 |
作者单位 | 1.Sun Yat Sen Univ, Sch Life Sci, Dept Biochem, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China; 2.Beijing Univ Chinese Med, Sch Life Sci, Beijing 100029, Peoples R China |
推荐引用方式 GB/T 7714 | Jia, Xin,Yuan, Shaochun,Wang, Yao,et al. The role of alternative polyadenylation in the antiviral innate immune response[J]. NATURE COMMUNICATIONS,2019,8. |
APA | Jia, Xin.,Yuan, Shaochun.,Wang, Yao.,Fu, Yonggui.,Ge, Yong.,...&Xu, Anlong.(2019).The role of alternative polyadenylation in the antiviral innate immune response.NATURE COMMUNICATIONS,8. |
MLA | Jia, Xin,et al."The role of alternative polyadenylation in the antiviral innate immune response".NATURE COMMUNICATIONS 8(2019). |
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