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DOI | 10.1038/s41467-018-08198-3 |
Global identification of Arabidopsis lncRNAs reveals the regulation of MAF4 by a natural antisense RNA | |
Zhao, Xinyue1,2; Li, Jingrui1,2; Lian, Bi1,2; Gu, Hanqing1,2; Li, Yan1; Qi, Yijun1,2 | |
2019-01-16 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2018 |
卷号 | 9 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | Long non-coding RNAs (lncRNAs) have emerged as important regulators of gene expression and plant development. Here, we identified 6,510 lncRNAs in Arabidopsis under normal or stress conditions. We found that the expression of natural antisense transcripts (NATs) that are transcribed in the opposite direction of protein-coding genes often positively correlates with and is required for the expression of their cognate sense genes. We further characterized MAS, a NAT-lncRNA produced from the MADS AFFECTING FLOWERING4 (MAF4) locus. MAS is induced by cold and indispensable for the activation of MAF4 transcription and suppression of precocious flowering. MAS activates MAF4 by interacting with WDR5a, one core component of the COMPASS-like complexes, and recruiting WDR5a to MAF4 to enhance histone 3 lysine 4 trimethylation (H3K4me3). Our study greatly extends the repertoire of lncRNAs in Arabidopsis and reveals a role for NAT-lncRNAs in regulating gene expression in vernalization response and likely in other biological processes. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000451621700004 |
WOS关键词 | GENOME-WIDE ANALYSIS ; LONG NONCODING RNAS ; SENSITIVE MALE-STERILITY ; EXPRESSION PROFILES ; GENE-EXPRESSION ; TRANSCRIPTS ; CHROMATIN ; ANNOTATION ; QUANTIFICATION ; FEATURES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/204172 |
专题 | 资源环境科学 |
作者单位 | 1.Tsinghua Univ, Sch Life Sci, Ctr Plant Biol, Beijing 100084, Peoples R China; 2.Tsinghua Peking Ctr Life Sci, Beijing 100084, Peoples R China |
推荐引用方式 GB/T 7714 | Zhao, Xinyue,Li, Jingrui,Lian, Bi,et al. Global identification of Arabidopsis lncRNAs reveals the regulation of MAF4 by a natural antisense RNA[J]. NATURE COMMUNICATIONS,2019,9. |
APA | Zhao, Xinyue,Li, Jingrui,Lian, Bi,Gu, Hanqing,Li, Yan,&Qi, Yijun.(2019).Global identification of Arabidopsis lncRNAs reveals the regulation of MAF4 by a natural antisense RNA.NATURE COMMUNICATIONS,9. |
MLA | Zhao, Xinyue,et al."Global identification of Arabidopsis lncRNAs reveals the regulation of MAF4 by a natural antisense RNA".NATURE COMMUNICATIONS 9(2019). |
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